Previously published ‘up-scaled’ model of complexation in ‘C60 fullerene - Ligand’ system was critically analyzed. The equations of the generalized ‘up-scaled’ model accounting for the polydispersity of the mixture were derived. The approximation of the published experimental data of spectrophotometric titration in the ‘C60 fullerene - Doxorubicin’ system was carried out. The generalized model fits the minimum in the titration curve and gives a satisfactory quantitative evaluation of the complexation process. The model can be used in different studies of C60 fullerene as a drug delivery system to damaged cells.
aggregation, C60 fullerene, doxorubucin, statistical-thermodynamic model
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