Nanogels are cross-linked particles based on hydrophilic polymers that have been formed at nanoscale level. In this work, the formation of nanogels occurred by ionic assembly in chitosan-heparin and heparin-poly (L-lysine) systems. Modeled compounds, namely, prednisolone and oligothymidine, were encapsulated in the resulting particles. pH-sensitive release was due to the ionic nature of macromolecules, and photosensitive release was achieved by using a special linker. The penetration of obtained particles into the intracellular space has also been studied.
nanogels, pH and photosensitive release, intracellular penetration
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