Saint Petersburg, St. Petersburg, Russian Federation
Integration of DNA with nanoparticles of noble metals makes it possible to obtain various structures with unique properties due to the synergistic activity of both components, which make it possible to create various nanoscale tools for use in theranostic, bioelectronics, biocatalysis, for probing, labeling and delivering biologically active agents. Such systems useful when building various three-dimensional constructions based on DNA origami and DNA-Lego technologies, which makes it possible to create composite materials with unique optical, physical and electrochemical properties. In such structures, the principle of base complementarity is usually used. Recently, however, investigators began to use not only unique architectural properties of DNA, but also the conformational capabilities of DNA, that ensure recognition of a wide variety of targets (from ions to proteins and supramolecular structures) for the formation of complexes with desired properties . The reduction of silver ions after the formation of their complexes with nitrogenous bases of DNA is studied in this research. The process of DNA metallization in solution is considered. It is shown that the optical properties of the formed structures depend on a number of factors - on the concentrations of the components, on the method of mixing, etc. The spectral properties of solutions containing high-molecular DNA with silver nanoparticles were regarded. The dynamic light scattering method and atomic force microscopy to analyze the size of nanoparticles obtained by chemical reduction of silver ions using silver nitrate were used. The analysis of the influence of DNA on the state of nanoparticles in solution was carried out.
silver nanoparticles, high molecular DNA, DNA metallization
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