It is known that any living organism consists of a significant amount of asymmetric compounds, and that asymmetric molecules can have a selective effect on other enantiomers. Two seemingly chemically identical molecules may have quite different effect on a living organism. This is especially important to consider when creating medicines, since stereoisomers of opposite types have different effects on the body: one form of drug can have a therapeutic effect, while the other form may not be assimilated at all, or be less active, and even cause serious complications, being toxic to the body. In the development of the concept of the role of chirality in the structure of biomacromolecules, for the first time a selection of drugs has been purposefully analyzed, classified according to the following criteria: the impact on the body, active isomer, type of drug and target impact. The analysis of drugs from the standpoint of chirality allowed us to determine which form of drugs has a therapeutic effect more often. The obtained results can be further used to establish the relationship between the chiral form of the drug and its effect on a specific target.
chirality, enantiomers, hierarchy of structures, proteins, DNA, drugs
1. Vasilenko I.A. i dr. Opticheskie izomery v farmacevtike. Razrabotka i registraciya lekarstvennyh sredstv, 2015, vyp. 1, s. 92-104. @@[Vasilenko I.A. et al. Optical isomers in the pharmaceutic. Drug development & registration, 2015, iss. 1, pp. 92-104. (In Russ.)]
2. Gardner M. Etot pravyy, levyy mir. M.: MIR, 1967, 265 s. @@[Gardner M. The Ambidextrous Universe. M.: MIR, 1967, 265 p. (In Russ.)]
3. Leffingwell J.C. Chirality & bioactivity I: pharmacology. Leffingwell Reports, 2003, vol. 3, no. 1, pp. 1-27.
4. Hramcova, E.A. Fotoinducirovannye processy perenosa zaryada v hiral'nyh svyazannyh sistemah. Dis. kand. him. nauk: 02.00.04. Novosibirsk, 2016. 103 s. @@[Khramtsova E.A. Photoinduced charge transfer processes in chiral coupled systems. PhD thesis: 02.00.04, Novosibirsk, 2016, 103 p. (In Russ.)]
5. Tverdislov V.A. i dr. Ot simmetriy - k zakonam evolyucii. I. Hiral'nost' kak instrument stratifikacii aktivnyh sred. Biofizika, 2012, t. 57, vyp. 1, s. 146-154. @@[Tverdislov V.A. et al. From Symmetries to the Laws of Evolution. I. Chirality as a Means of Active Media Stratification. Biophysics, 2012, vol. 57, iss. 1, pp. 146-154. (In Russ.)]
6. Tverdislov V.A. Hiral'nost' kak pervichnyy pereklyuchatel' ierarhicheskih urovney v molekulyarno-biologicheskih sistemah. Biofizika, 2013, t. 58, vyp. 1, s. 159-164. @@[Tverdislov V. A. Chirality as a Primary Switch of Hierarchical Levels in Molecular Biological Systems. Biophysics, 2013, vol. 58, iss. 1, pp. 159-164. (In Russ.)]
7. Tverdislov V.A. [i dr.] Ot avtovolnovyh mehanizmov samoorganizacii k molekulyarnym mashinam. Izvestiya RAN. Ser. fizicheskaya, 2015, t. 79, № 12, s. 1728-1732. @@[Tverdislov V.A. [et al.] From autowave mechanisms of self-organization to biological machines. Bulletin of the Russian Academy of Sciences. Physics, 2015, vol. 79, no. 12, pp. 1728-1732. (In Russ.)]
8. Tverdislov V.A. [i dr.] Periodicheskaya sistema hiral'nyh struktur v molekulyarnoy biologii. Biofizika, 2017, t. 62, vyp. 3b s. 421-434. @@[Tverdislov V.A. [et al.] Periodic System of Chiral Structures in Molecular Biology. Biophysics, 2017, vol. 62, iss. 3, pp. 421-434. (In Russ.)]
9. Finkel'shteyn A.V., Pticyn O.B. Fizika belka: kurs lekciy s cvetnymi i stereoskopicheskimi illyustraciyami i zadachami. M.: KDU, 2012, 456 s. @@[Finkelstein A.V., ptitsyn O.B. Protein Physics: A Course of Lectures. M.: KDU, 2012, 456 p. (In Russ.)]
