The investigation of ferrokinetics, total antioxidant activity, and plasma lactoferrin concentration in the plasma of children 0-17 years old with iron deficiency (iron-deficiency anemia and latent iron deficiency) before and after treatment was made. It was shown that after treatment with ferro drug group of adolescent patients, ferritin (from 5.9 to 10.3 ng/ml) and iron (from 11.5 to 23.5 mmol/l) concentration in blood serum increased, but total plasma antioxidant activity decreased in contrast with data before treatment (~20%, Р < 0.05). While iron deficiency lactoferrin concentration in plasma raised with a maximum in a group of children 0-3-month-old. During ferrotherapy lactoferrin concentration also increased in comparison with the results before treatment. Obtained results showed the necessity of considering the level total antioxidant activity of plasma children with iron deficiency during treatment with fero drugs.
iron deficiency, ferrokinetics, total antioxidant activity, lactoferrin, children
1. Tandara L. et al. Iron metabolism: current facts and future directions. Biochemia Medica, 2012, vol. 22, no. 3, pp. 311-328.
2. Zakharova I.N. et al. Correction of iron deficiency: background and current aspects. Voprosy practicheskoy pediatrii, 2014, vol. 9, no. 4, pp. 2-7.
3. WHO. Programme and project: WHO. Available at: http://www.who.int/nutrition/topics/ida/en/index.html. Accessed August 10th 2011.
4. Kassebaum N.J. et al. A systematic analysis of global anemia burden from 1990 to 2010. Blood, 2014, vol. 123, pp. 615-624.
5. Benoistr B. et al. Worldwide prevalence of anaemia 1993-2005: WHO global database on anemia. Geneva: WHO Press, 2008, 41 p.
6. Ward P.P., Connely O.M. Lactoferrin: role in iron homeostasis and host defense against microbial infection. Biometals, 2004, vol. 17, no. 3, pp. 203-208.
7. Aliyeva A.M., Namazova-Baranova L.S., Kazyukova T.V., Studentkin V.M. The iron metabolism in children is normal also at infectious diseases. Detskiye infekcii, 2017, vol. 1, pp. 21-27.
8. Djukareva-Bezdenezhnykh S. Maintenance the basic haemopoetic components of infants at feeding by breast milk. Perinatalogiya i pediatria, 2008, vol. 3, pp. 108-111.
9. Gao X. et al. Nonparametric Multiple Comparison Procedures for Unbalanced One-Way Factorial Designs. JSPI, 2008, vol. 138, no. 8, pp. 2574-2591.
10. R Core Team A language and environment for statistical computing. R Foundation for Statistical Computing. Vienna, Austria, 2013. Available at: http://www.R-project.org.
11. Kuznetsov I.A. , Potievskaya V.I., Kachanov I.V., Kuraleva O.O Laktoferrin's role in biological circles of the person. Sovremennie problemi nauki i obrazovania, 2017, vol. 3, pp. 69.
12. Zubritskaya G.P., Klimkovich N.N., Kutko A.G., Venskaya E.I., Skorobogatova A.S, Lukyanenko L.M., Kozarezova T.I., Slobozhanina E.I. Changes of the glutathione range of the antioxidant system in erythrocytes of children with iron deficiency anemia. Laboratornaya diagnostica. Vostochnaya Evropa, 2019, vol. 8, no. 2, pp. 217-226.