Microporous nanomaterials can provide interesting tools for different goals from bioimaging to the delivery of bioactive molecules. In this study, the procedure based on cryoapproaches was designed to formulate the nanoparticles of clinoptilolite from Zeolites mineral family. Applying scanning electron microscopy, clinoptilolite particles were imaged. Retting the nanoparticles in the ethanol solution of phosphatidylcholine (lecithin), the particle was encapsulated in lecitin envelope. Registering the diminution of optical density (OD 235) for ethanol/lecitin solution, the sorption of lecitin by clinoptilolite nanoparticles was studied with UV spectrometry. The kinetics of lecitin/clinoptilolite complex development was shown to exhibit intricate behavior, when the adsorption of lecitin was followed with its gradual desorption resulting in the increase of lecitin content in ethanol solution back toward the original level. The distribution of final size for lecitin/clinoptilolite complex was determined with dynamic light scattering technique. To our knowledge, there are no reports of natural zeolite nanoparticles that were used as the platform for nanosize capsule with phospholipids shell.
phosphatidylcholine (lecithin), UV spectrometry, scanning electron microscopy, nanocapsule
1. Simonoska-Crcarevska M., Glavas-Dodov M., Goracinova K. Chitosan coated Ca-alginate microparticles loaded with budesonide for delivery to the inflamed colonic mucosa. Eur. J. Pharmaceutics and Biopharmaceutics, 2008, vol. 68, pp. 565-578.
2. Render D., Samuel T., King H., Vig M., Jeelani S., Babu R.J., Rangari V. Biomaterial-Derived Calcium Carbonate Nanoparticles for Enteric Drug Delivery. J. Nanomaterials, 2016, vol. 2016, pp. 1-8.
3. Allemann E., Leroux J.-C., Gurny R. Polymeric nano- and microparticles for the oral delivery of peptides and peptidomimetics. Advanced Drug Delivery Rev., 1998, vol. 34, pp. 171-189.
4. Hu Y., Jiang X., Ding Y., Ge H., Yuan Y., Yang C. Synthesis and characterization of chitosan-poly (acrylic acid) Nanoparticles. Biomaterials, 2002, vol. 23, pp. 3193-3201.
5. Jintapattanakit A., Junyaprasert V.B., Maob S., Sitterberg J., Bakowsky U., Kissel T. Peroral delivery of insulin using chitosan derivatives: A comparative study of polyelectrolyte nanocomplexes and nanoparticles. Int. J. Pharmaceutics, 2007, vol. 342, pp. 240-249.
6. Zhu J., Hayward R.C. Hierarchically Structured Microparticles Formed by Interfacial Instabilities of Emulsion Droplets Containing Amphiphilic Block Copolymers. Angew Chem. Int. Ed., 2008, vol. 47, pp. 2113-2116.
7. Yu X., Khalil A., Dang P.N., Alsberg E., Murphy W.L. Multilayered Inorganic Microparticles for Tunable Dual Growth Factor Delivery. Adv. Funct. Mater., 2014, vol. 24, pp. 3082-3093.
8. Kar S. An Overview of Recent Advances in Application of Some Inorganic Materials-Biological and Technological Perspectives J. Biotechnol. Biomater., 2016, vol. 6, pp. 565-578.
9. Stefanache A., Ignat M., Peptu C.A., Diaconu A., Stoleriu I., Ochiuz L. Development of a Prolonged-Release Drug Delivery System with Magnolol Loaded in Amino-Functionalized Mesoporous Silica Appl. Sci., 2017, vol. 7, pp. 237-250.
10. Kojića D., Pajevića S., Jovanović-Galovića A., Puraća, J.E., Škondrićb S., Milovaca S., Popovića Ž., Grubor-Lajšić G. Efficacy of natural aluminosilicates in moderating drought effects on the morphological and physiological parameters of maize plants (Zea mays l.). J. Soil Sci. and Plant Nutrition, 2012, vol. 12, pp. 113-123.
11. Yada R.Y., Buck N., Canady R., DeMerlis C., Duncan T., Janer G., Juneja L., Lin M., McClements D.J., Noonan G., Oxley J., Sabliov Cr., Tsytsikova L., Vázquez-Campos S., Yourick J., Zhong Q., Thurmond S. Engineered Nanoscale Food Ingredients: Evaluation of Current Knowledge on Material Characteristics Relevant to Uptake from the Gastrointestinal Tract. Food Science and Food Safety, 2014, vol. 13, pp. 730-744.
12. Bohacs K., Faitli J., Bokanyi L., Mucsi G. Control of Natural Zeolite Properties by Mechanical Activation in Stirred Media Mill. Arch. Metall. Mater., 2017, vol. 62, (2B), pp. 1399-1406.
13. Hazra D.K. Nano-formulations: High Definition Liquid Engineering of Pesticides for Advanced Crop Protection in Agriculture. Advances in Plants & Agriculture Research, 2017, vol. 6, pp. 00211-00212.
14. Pellegrino P., Mallet B., Delliaux S., Jammes Y., Guieu R., Schaf O. Zeolites are effective ROS-scavengers in vitro. Biochemical and Biophysical Research Communications, 2011, vol. 410, pp. 478-483.
15. Bacakova L., Vandrovcova M., Kopova I., Jirka I. Applications of zeolites in biotechnology and medicine - a review. Biomater. Sci., 2018, vol. 6, pp. 974-989.
16. Selim M.M., El-Mekkawi D.M., Aboelenin R.M.M., Sohair A.S.A., Ghada M.M. Preparation and characterization of Na-A zeolite from aluminum scrub and commercial sodium silicate for the removal of Cd2+ from water. J. Association of Arab Universities for Basic and Applied Sciences, 2017, vol. 24, pp. 19-25.
17. Johnson E.B.G., Arshad S.E. Hydrothermally synthesized zeolites based on kaolinite: A review. Appl. Clay Sci., 2014, vol. 98, pp. 215-221.
18. Severance M.A. Nanocrystalline Zeolites: Synthesis, Mechanism, and Applications. Dissertation for the Degree Doctor of Philosophy in the Graduate School of The Ohio State University, 2014.
19. Tian Y. Synthesis and Characterization of Crystalline Microporous Materials: Investigation of New Synthetic Routes. A Thesis for the Degree of PhD at the University of St Andrews, 2014.
20. Mintova S., Grand J., Valtchev V. Nanosized zeolites: Quo Vadis? C. R. Chimie, 2016, vol. 19, pp. 183-191.
21. Tiburu E.K., Salifu A., Aidoo E.O., Fleischer H.N.A., Manu G., Yaya A., Zhou H., Efavi J.K. Formation of Chitosan Nanoparticles Using Deacetylated Chitin Isolated from Freshwater Algae and Locally Synthesized Zeolite A and their Influence on Cancer Cell Growth. J. Nano Research, 2016, vol. 48, pp. 156-170.
22. Tosheva L., Belkhair S., Gackowski M., Malic S., Al-Shanti N., Verran J. Rapid screening of the antimicrobial efficacy of Ag zeolites. Colloids and Surfaces B: Biointerfaces, 2017, vol. 157, pp. 254-260.
23. Elhassan A.M. Determination of the Natural Zeolites Characteristics in Sudan Country. Int. J. Current Advanced Res., 2016, vol. 5, pp. 1304-1310.
24. Bertucci A., Lülf H., Septiadi D., Manicardi A., Corradini R., De Cola L. Intracellular Delivery of Peptide Nucleic Acid and Organic Molecules Using Zeolite-L Nanocrystals. Adv. Healthcare Mater, 2014, vol. 3, pp. 1812-1817.
25. Li Le-Le, Zhang R., Yin L., Zheng K., Qin W., Selvin P.R., Lu Y. Biomimetic Surface Engineering of Lanthanide-Doped Upconversion Nanoparticles as Versatile Bioprobes. Angew Chem. Int. Ed. Engl., 2012, vol. 51, pp. 6121-6125.
26. Euliss L.E., DuPont J.A., Gratton S., DeSimone J. Imparting size, shape, and composition control of materials for nanomedicine. Chem. Soc. Rev., 2006, vol. 35, pp. 1095-1104.
27. Grenha A., Remunan-Lopez C., Carvalho E.L.S., Seijo B. Microspheres containing lipid/chitosan nanoparticles complexes for pulmonary delivery of therapeutic proteins. Eur. J. Pharmaceutics and Biopharmaceutics, 2008, vol. 69, pp. 83-93.
28. Shchukina E.M., Shchukin D.G. Layer-by-layer coated emulsion microparticles as storage and delivery tool. Current Opinion in Colloid & Interface Science, 2012, vol. 17, pp. 281-289.
29. Fricker G., Kromp T., Wendel A., Blume A., Zirkel J., Rebmann H., Setzer C., Quinkert R., Martin F., Müller-Goyman C. Phospholipids and Lipid-Based Formulations in Oral Drug Delivery. Pharm. Res., 2010, vol. 27, pp. 1469-1486.
30. Baldassarre F., Allegretti C., Tessaro D., Carata E., Citti C., Vergaro V., Nobile C., Cannazza G., D’Arrigo P., Mele A., Dini L., Ciccarella G. Biocatalytic Synthesis of Phospholipids and Their Application as Coating Agents for CaCO3 Nano-crystals: Characterization and Intracellular Localization Analysis. ChemistrySelect, 2016, vol. 1, pp. 6507-6514.
31. Ensign L.M., Cone R., Hanes J. Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers. Advanced Drug Delivery Reviews, 2012, vol. 64, pp. 557-570.
32. Kotta S., Wadood Khan A., Pramod K., Ansari S.H., Sharma R.K., Ali J. Exploring oral nanoemulsions for bioavailability enhancement of poorly water-soluble drugs. Expert Opin. Drug Deliv., 2012, vol. 9, pp. 585-598.
