Studied the morphology of the dried samples of blood plasma of patients with cancer of the brain. The structural features of dried blood plasma drops of patients diagnosed with brain tumors of various degrees were revealed. It is shown that it is possible to clarify the diagnosis by assigning the tumor to different types. Semi-quantitative results of spatial distribution of calcium on the surface of a dried drop of biological fluids and in layers using the method of laser atomic emission spectrometry were obtained. It is shown that the method of laser atomic emission spectrometry makes it possible to quantify changes in protein centers and is an operational highly sensitive tool in the diagnosis of diseases. The analysis of blood plasma samples was performed using atomic emission multichannel spectrometry. An integral assessment of the metabolism of vital elements (VNE) is given. A significant increased content of aluminum, iron, calcium, and zinc was found both before and after the operation. The identified microelementoses can affect the features of the clinical course of the disease and justify the expediency of supplementing therapy with medication complexes for the correction of mineral metabolism. The obtained experimental data can be the basis for further development of the methodology for early diagnosis of violations of the level of functional reserves of the body and the development of a system of rehabilitation measures.
biological fluid, drop morphology, laser atomic-emission spectrometry, double laser pulses, spatial distribution, layer-by-layer analysis, calcium
1. Kobyakov G.L., Smolin A.V. Onkologiya. Novye strategii v lechenii zlokachestvennyh gliom: kratkiy obzor nauchnyh publikaciy ezhegodnogo s'ezda obschestva neyroonkologov (SNO), 2011, № 7, c. 41-49.
2. Korytova R.N., Zhabina R.M., Maslyukova E.A., Meshechkin A.V. Kombinirovannoe lechenie opuholey golovnogo mozga razlichnogo geneza. Palliativnaya medicina, 2010, № 4, c. 49-54.
3. Lukovskaya N.D. Strukturno-funkcional'noe sostoyanie syvorotochnogo al'bumina u bol'nyh rakom golovy i shei pri luchevoy terapii. Sibirskiy onkologicheskiy zhurnal, 2010, pril. № 1, c. 71-72.
4. Lyubimova N.V., Timofeev Yu.S., Kushlinskiy N.E. Neyrospecificheskie belki v syvorotke krovi u bol'nyh s opuholyami golovnogo mozga i nevrologicheskimi zabolevaniyami neopuholevoy etiologii. Mediko-biologicheskie i social'no-psihologicheskie problemy bezopasnosti v chrezvychaynyh situaciyah, 2016, № 3, c. 90-95.
5. Shabalin V.N., Shatohina S.N. Morfologiya biologicheskih zhidkostey cheloveka. M.: Hrizostom, 2001, 302 s.
6. Maksimov S.A. Morfologiya tverdoy fazy biologicheskih zhidkostey kak metod diagnostiki v medicine. Byulleten' sibirskoy mediciny, 2007, № 4, s. 80-85.
7. Kraevoy S.A., Koltovoy N.A. Diagnostika po kaple krovi. Kristallizaciya biozhidkostey. Kniga 1. Otkrytaya kaplya. V 4 kn. M. 2013, c. 67-71.
8. Sidorenko Yu.S., Shihlyarova A.I., Sergost'yanc G.Z. Regional'nye osobennosti morfologii krovi bol'nyh rakom legkogo: processy samoorganizacii v dinamike hirurgicheskogo lecheniya i autogemotransfuzii. Vestnik yuzhnogo nauchnogo centra RAN, 2005, t. 1, № 4, s. 64-71.
9. Komarov R.N., Gordecov A.S., Komarov N.V., Kanashkin O.V. Infrakrasnaya spektroskopiya syvorotki krovi v diagnostike onkozabolevaniy. Nizhegorodskiy medicinskiy zhurnal, t. 2996, № 1, s. 98-100.
10. Buloychik Zh.I. i dr. Morfologicheskoe i spektrofotometricheskoe issledovanie plazmy krovi pacientov s anevrizmoy sosudov golovnogo mozga. Zhurnal BGU, Fizika, 2018, № 1, c. 9-17.
11. Buloychik Zh.I., Veremchuk A.N., Russko T.A., Maslova G.T., Mavrichev A.S. Morfologicheskoe i spektrometricheskoe izuchenie obrazcov vysohshih kapel' krovi onkologicheskih bol'nyh. Vestnik BGU, 2015, ser. 1, № 2, s. 24-30.
12. Savkov A.V., Sergey M.A., Buloychik Zh.I., Maslova G.T., Mavrichev A.S., Derzhavec L.A. Ispol'zovanie morfostrukturnogo analiza i lazernoy atomno-emissionnoy spektrometrii vysohshih kapel' plazmy krovi dlya diagnostiki raka prostaty. Vestnik BGU, 2016, ser. 1, № 3, s. 51-62.
13. Buloychik Zh.I., Maslova G.T., Korzyuk V.V., Sergey M.A., Mavrichev A.S., Derzhavec L.A. Primenenie atomno-emissionnoy spektrometrii vysohshih kapel' plazmy krovi v diagnostike i lechenii opuholey mozga. Zh. Belgosuniversiteta, fizika, 2017, № 2, s. 17-26.
14. Didkovskiy Ya.I., Kovalenko M.N., Min'ko A.A., Posledovich M.R. Razrabotka i primenenie spektral'nyh priborov s mnogokanal'nymi fotopriemnymi ustroystvami. Vestnik BGU, 2013, ser. 1, № 3, s. 20-24.
