It was obtained that zinc ions under interaction with human erythrocytes in vitro haven’t a visible effect on the quantity and degree of packing of detergent-resistant membranes (DRMs) or lipid rafts. At the same time, zinc ions can modify the lipid rafts structure (changing the localization as a protein-DRM marker - stomatin, as an integral protein - protein band 3) and lateral distribution of cholesterol in the erythrocyte membranes. Moreover, it was shown that DRMs destruction шт human erythrocytes as a result of in vitro extraction of membrane cholesterol leads to a loss of the functional activity of the membrane-bound integral protein-transporter MRP1.
human erythrocytes, lipid rafts, membrane cholesterol, zinc ions, protein MRP1
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