Moscow, Moscow, Russian Federation
Moscow, Moscow, Russian Federation
Hyaluronic acid (Ha - biopolymer, the component of cell matrix, highemolecular component, which simple structure do not changes and identical for all mammals) influence on calcium hydroxyapatite precipitation (Ca10(PO4)6(ОН)2, HА) in water system CaCl2-(NH4)2HPO4-Ha-H2O (25 0С) estimated. Manufactured nanosized organomineral composited (OMC) HA/Ha with compositions Ca10(PO4)6(OH)2-(Ha)х·zH2O, х = 0.1, 0.2, 0.3; z = 5.3-10.0 with physical and chemical methods (X-ray, chemical and thermal analysis, infrared spectroscopy) studied, the fundamental couplings composition - structure - properties estimated and directed synthesis methods for OMC HA/Ha (prospective materials for bone implants) was proposed.
hydroxyapatite, hyaluronic acid, nanocomposute, synthesis, properties
1. Dorozhkin S.V. Medical Application of Calcium Orthophosphate Bioceramics. BIO, 2011, vol. 1, pp. 1-51. DOI:https://doi.org/10.5618/bio.2011.v1.n1.1.
2. Elliot J.C. Structure, chemistry of apatites and other calcium orthophosphates. Amsterdam: Elsevier Science, 1994, 350 p.
3. Kasavina B.S., Torbenko V.P. Zhizn' kostnoy tkani. 2-e izd. M.: Nauka, 1979, 176 s. @@Kasavina B.S., Torbenko V.P. The live of bone tissue. 2-edich. M.: Science, 1979, 176 p. (In Russ.)
4. Habarov V.N., Boykov P.Ya., Selyanin M.A. Gialuronovaya kislota: poluchenie, svoystva, primenenie v biologii i medicine. M: Prakticheskaya medicina, 2012, 224 s. @@Khabarov V.N., Boikov P.J., Seljanin M.A. Hyaluronic acid: preparing, properties, application in biology and medicine. M: Practical Medicine, 2012, 224 p. (In Russ.)
5. Habarov V.N. Biohimiya gialuronovoy kisloty. M.: Tiso Print, 2016, 292 s. @@Khabarov V.N. Biochemy of hyaluronic acis. M.: Tiso Print, 2016, 292 p. (In Russ.)
6. Orlovskiy V.P., Rodicheva G.V., Ezhova Zh.A., Koval' E.M., Suhanova G.E. Izuchenie usloviy obrazovaniya gidroksilapatita v sisteme CaCl2 - (NH4)2HPO4 - NH4OH - H2O (25 oC). Zhurn. neorg. himii, 1992, t. 37, № 4, s. 881-883. @@Orlovskii V.P., Rodicheva G.V., Ejova J.A., Koval E.M., Sukhanova G.E. The study of formation of hydroxyapatite in system CaCl2 - (NH4)2HPO4 - NH4OH - H2O (25 oC). J. Inorg. Chem., 1992, vol. 37, no. 4, rr. 881-883. (In Russ.)
7. Shvarcenbah G., Flashka G. Kompleksonometricheskoe titrovanie. M.: Himiya, 1970. s. 172. @@Shvartsenbach G., Flashka G. Kompleksonometric titration. M.: Chmistry, 1970, p. 172. (In Russ.)
8. Gorelik S.S., Skakov Yu.A., Rastorguev L.N. Rentgenograficheskiy i elektronno-opticheskiy analiz. M.: «MISiS», 2002, 360 s. @@Gorelik S.S., Skakov Ju.A., Rastorguev L.N. Rentgenographycal and electronno-optical analysis. M.: “MISiS”, 2002, 360 p. (In Russ.)
9. Powder diffraction file (inorganic phases). Joint Committee on Powder Diffraction Standards (JCPDS) File № 9-432, International Centre of Diffraction Data, Newton Square, PA, 1980.
10. Hench L.L. Bioceramics: from concept to clinic. J. Amer. Ceram. Soc., 1991, vol. 74, no. 7, p. 1487-1510.
11. Zaharov N.A., Bokarev V.P., Gornev E.S., Nechiporenko A.P. Vliyanie uglerodnyh nanotrubok na kristallizaciyu i svoystva nanorazmernogo gidroksiapatita kal'ciya. Elektronnaya tehnika. Seriya 3: Mikolelektronika, 2019, № 1 (173), s. 55-60. @@Zakharov N.A., Bokarev V.P., Gornev E.S., Nechiporenko A.P. The carbon nanotubes influence on crystallization and properties of nanosized calcium hydroxyapatite. Eltctronic Technik. Part 3: Microelectronics, 2019, № 1 (173), pp. 55-60. (In Russ.)
12. Zaharov N.A., Bokarev V.P., Gornev E.S., Nechiporenko A.P., Matveev V.V., Aliev A.D., Kiselev M.R., Shelehov E.V., Koval' E.M., Zaharova T.V., Orlov M.A. Vliyanie oksida grafena na kristallizaciyu i svoystva nanorazmernogo gidroksiapatita kal'ciya. Elektronnaya tehnika. Seriya 3: Mikroelektronika, 2019, № 3 (179), s. 46-51. @@Zakharov N.A., Bokarev V.P., Gornev E.S., Nechiporenko A.P., Matveev V.V., Aliev A.D., Kiselev M.R., Shelichov E.V., Koval E.M., Zakharova T.V., Orlov M.A. The graphene oxyde influence on crystallization and properties of nanosized calcium hydroxyapatite. Eltctronic Technik. Part 3: Microelectronics, 2019, no. 3 (179), pp. 46-51. (In Russ.)