Dubna, Moscow, Russian Federation
Dubna, Moscow, Russian Federation
Dubna, Moscow, Russian Federation
In this paper, we have proposed a model for analyzing the properties of neural networks in the hippocampus with different types of NMDA receptors: GluN1/GluN2A, GluN1/GluN2B and GluN1/GluN2A/GluN2B. The properties of the neural network of the hippocampus’s CA3 region with modified structure of NMDA receptors were studied and the electrophysiological characteristics of the neural network model were obtained depending on the structures of the NMDA receptor’s ion channel. Analysis of the network activity of neurons with different types of NMDA revealed insignificant changes in the conductivity of the ion channel and local potential depending on the subunits that make up the receptor. In the case of the GluN1/GluN2A NMDA receptor model, a decrease in the amplitude of theta-rhythm and increase of gamma-rhythm was observed in comparison with the native forms of the NMDA receptor. For the triheteromer GluN1/GluN2A/GluN2B, no significant changes of neural network activity were found in comparison with GluN1/GluN2B.
hippocampus, NMDA receptor, molecular dynamics, neural network
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