Moscow, Moscow, Russian Federation
Moscow, Moscow, Russian Federation
Moscow, Moscow, Russian Federation
Moscow, Moscow, Russian Federation
The ability to reduce the isotopic composition of hydrogen in the internal environment of the body to influence the physiology of the organs of the endocrine system is a new and practically unexplored direction in science. The aim of the work was to study the morphological and functional changes in the thyroid gland of male rats after a two-week decrease in the content of deuterium in the internal environment of the body. The experiment was carried out on male Wistar rats fed deuterium-reduced water instead of drinking water for 2 weeks. The main effect exerted by water with a reduced content of deuterium on the body is a gradual decrease in the content of deuterium in liquid media and tissues due to isotope exchange reactions. Two weeks after the start of the experiment, the concentrations of thyroid hormones were determined: total and free thyroxine, total and free triiodothyronine, and thyroid-stimulating hormone. Histological and morphometric examination of thyroid preparations was carried out. Morphological and functional changes in the thyroid gland of male rats after a two-week reduction of the deuterium content in the internal environment of the body was studied. A prolonged decrease in deuterium influx led to structural changes in the thyroid gland and its secretory activity and were associated with hypothalamic-pituitary hypothyroidism due to a decrease in the synthesis of thyroid-stimulating hormone.
deuterium, protium, isotope mechanism, thyroid gland, thyroid hormones
1. Basov A.A., Baryshev M.G., Bykov I.M., Pavlyuchenko I.I., Dzhimak S.S., Sepiashvili R.I. The effect of water with a modified isotopic composition on the intensity of free radical processes in an experiment on laboratory animals. Allergology and immunology, 2012, vol. 13, no. 4, pp. 314-320. (In Russ.)
2. Dzhimak S.S., Basov A.A., Fedulova L.V., Dydykin A.S., Bykov I.M., Lyasota O.M., Naumov G.N., Baryshev M.G. Correction of metabolic processes in rats with chronic endotoxicosis using isotope (D/H) exchange reactions. News of the Russian Academy of Sciences. Biological series, 2015, no. 5, pp. 518-527, doi:https://doi.org/10.7868/S0002332915050069. (In Russ.)
3. Somlyai G., Javaheri B., Davari H., Gyöngyi Z., Somlyai I., Tamaddon K.A., Boros L.G. Pre-clinical and clinical data confirm the anticancer effect of deuterium depletion. Biomacromol. J., 2016, vol. 2, no. 1, pp. 1-7, doi:https://doi.org/10.1016/j.eujim.2016.08.068.
4. Halenova T., Zlatskiy I., Syroeshkin A., Maximova T., Pleteneva T. Deuterium-depleted water as adjuvant therapeutic agent for treatment of diet-induced obesity in rats. Molecules, 2019, vol. 25, no. 1, pp. 23, doi:https://doi.org/10.3390/molecules25010023.
5. Yaglova N.V. Disorders of the secretory cycle of follicular thyrocytes and their correction with thyroid-stimulating hormone in the experimental syndrome of non-thyroid diseases. Bulletin of Experimental Biology and Medicine, 2011, vol. 152, no. 8, pp. 215-219. (In Russ.)
6. Zlatska A., Gordiienko I., Vasyliev R., Zubov D., Gubar O., Rodnichenko A., Syroeshkin A., Zlatskiy I. In Vitro Study of Deuterium Effect on Biological Properties of Human Cultured Adipose-Derived Stem Cells. ScientificWorldJournal, 2018, vol. 2018, p. 5454367, doi:https://doi.org/10.1155/2018/5454367.
7. Yaglova N.V., Obernikhin S.S., Timokhina E.P., Yaglov V.V. The response of the pituitary-thyroid axis to a short-term change in the content of deuterium in the body. Bulletin of Experimental Biology and Medicine, 2021, vol. 171, no. 2, pp. 232-234, doi:https://doi.org/10.47056/0365-9615-2021-171-2-232-234. (In Russ.)
