E.I. Chazov National Medical Research Centre of Cardiology
Moscow, Moscow, Russian Federation
Moscow, Moscow, Russian Federation
Moscow, Moscow, Russian Federation
Lomonosov Moscow State University
Moscow, Moscow, Russian Federation
Moscow, Moscow, Russian Federation
Moscow, Moscow, Russian Federation
Lomonosov Moscow State University
Moscow, Moscow, Russian Federation
Dinitrosyl iron complexes (DNICs) are important metabolites of nitric oxide (NO) with a wide range of biological activity. The properties of these complexes are determined not only by NO-ligands, but also by other components included in their composition. Using EPR spectroscopy, it was shown that iron in the DNICs can be bound to carnosine, L-ergothioneine and ADP. New variants of DNICs are formed with the participation of a nitroxyl anion, which is a product of one-electron reduction of NO. In model systems, DNICs associated with carnosine and ergothioneine reduce the level of various free radicals. These DNICs intercept the superoxide anion radical, which is a precursor to other reactive oxygen and nitrogen species. At the same time, carnosine-bound DNICs reduce the concentration of organic free radicals in a system containing a nitroxyl anion, iron ions and tert-butyl hydroperoxide. On the other hand, DNICs associated with ergothioneine and ADP may play an important role in the protection of mitochondria. It has been suggested that the new DNICs may be components of antioxidant systems localized in various tissues of the body, as well as redox triggers regulating the cellular response to oxidative stress.
dinitrosyl iron complexes, nitric oxide, free radical, EPR spectroscopy
1. Lehnert N. et al. The Biologically Relevant Coordination Chemistry of Iron and Nitric Oxide: Electronic Structure and Reactivity. Chem. Rev., 2021, vol. 121, no. 24, pp. 14682-14905.; DOI: https://doi.org/10.1021/acs.chemrev.1c00253; EDN: https://elibrary.ru/EEKDUR
2. Vanin A.F. Physico-Chemistry of Dinitrosyl Iron Complexes as a Determinant of Their Biological Activity. Int. J. Mol. Sci., 2021, vol. 22, p. 10356.; DOI: https://doi.org/10.3390/ijms221910356; EDN: https://elibrary.ru/CKMCHK
3. Shumaev K.B. et al. Interaction of reactive oxygen and nitrogen species with albumin- and methemoglobin-bound dinitrosyl-iron complexes. Nitric Oxide, 2008, vol. 18, no. 1, pp. 37-46.
4. Shumaev K.B. et al. Protective Effect of Dinitrosyl Iron Complexes with Glutathione in Red Blood Cell Lysis Induced by Hypochlorous Acid. Oxid. Med. Cell. Longev., 2019, vol. 2019, art. id 2798154, 12 p.
5. Shumaev K.B. et al. Probable mechanism of antioxidant action of iron dinitrosyl complexes. Biomedical Chemistry, 2021, vol. 67, no. 2, pp. 162-168. (In Russ.); DOI: https://doi.org/10.18097/PBMC20216702162; EDN: https://elibrary.ru/JCXGWG
6. Kosmachevskaya O.V. et al. Protective Effect of Dinitrosyl Iron Complexes Bound with Hemoglobin on Oxidative Modification by Peroxynitrite. Int. J. Mol. Sci., 2021, vol. 22, p. 13649.; DOI: https://doi.org/10.3390/ijms222413649; EDN: https://elibrary.ru/WUVVLC
7. Shumaev K.B. et al. Dinitrosyl iron complexes: Formation and antiradical action in heart mitochondria. Biofactors, 2018, vol. 44, no. 3, pp. 237-244.; DOI: https://doi.org/10.1002/biof.1418; EDN: https://elibrary.ru/YBWGKT
8. Paul B.D., Snyder S.H. The unusual amino acid L-ergothioneine is a physiologic cytoprotectant. Cell Death Differ., 2010, vol. 17, no. 7, pp. 1134-1140.
9. Prokopieva et al. Use of Carnosine for Oxidative Stress Reduction in Different Pathologies. Oxid. Med. Cell. Longev., 2016, vol. 2016, art. id 2939087, 8 p.
10. Li Q. et al. Nitrosothiol Formation and Protection against Fenton Chemistry by Nitric Oxide-induced Dinitrosyliron Complex Formation from Anoxia-initiated Cellular Chelatable Iron Increase. J. Biol. Chem., 2014, vol. 289, no. 29, pp. 19917-19927.; DOI: https://doi.org/10.1074/jbc.M114.569764; EDN: https://elibrary.ru/UOWTJF
