Simferopol, Simferopol, Russian Federation
Simferopol, Simferopol, Russian Federation
Simferopol, Simferopol, Russian Federation
The paper considers the indicators of tissue oxidative in rats after 10-fold exposure to low-intensity electromagnetic radiation of the millimeter range. The experiment was carried out on 40 mature male rats of the Wistar line weighing 200-220 g, which were kept in a vivarium with a natural light regime. The animals were divided into 2 groups of 20 rats each. The animals in the first group were biological controls and were in normal vivarium conditions, the animals of the second group were exposed to EHF EMR for 10 sessions daily, in the morning. On the 10th day of EHF exposure, tissue fluorescence indicators were recorded by the diagnostic complex “LAZMA MC” (Modification of LAZMA-MC-III, LAZMA, Moscow, Russia). The results of the study showed that rats exposed to 10-fold EHF exposure had an increase in the values of normalized NADH fluorescence amplitudes and an increase in FAD amplitudes by 82.5% (p<0.05) and 42.6% (p<0.05), as well as redox potential - by 36.9% (p<0.05), respectively, compared to with control. These changes indicate that 10-fold exposure to low-intensity EHF EMR causes an increase in the contribution of aerobic metabolism in rats mainly due to oxidative phosphorylation, leads to activation of the respiratory chain. It can be assumed that these changes in oxidative metabolism are determined primarily by the process of adaptation of microcirculatory blood flow to the needs of tissues for nutrients and the removal of metabolites.
tissue oxidative metabolism, low-intensity millimeter radiation, nicotinamide adenine dinucleotide, flavinadenine dinucleotide, redox potential
1. Kurganova L.N. Lipid peroxidation is one of the possible components of a rapid reaction to stress. Vestnik of Lobachevsky State University of Nizhni Novgorod. Biology, 2001, no. 2, pp. 74-76. (In Russ.)
2. Moskvin S.V., Antipov E.V., Zarubina E.G., Ryazanova E.A. Oxygen exchange effectiveness after application of different gels based on hyaluronic acid laser-phoresis. Bulletin of Aesthetic Medicine, 2011, vol. 10, no. 3, pp. 48-55. (In Russ.)
3. Novikov V.E., Levchenkova O.S., Pozhilova Ye.V. Role of reactive oxygen species in cell physiology and pathology and their pharmacological regulation. Reviews on Clinical Pharmacology and Drug Therapy, 2014, vol. 12, no. 4, pp. 13-21. (In Russ.)
4. Chuyan E.N., Birukova E.A., Ravaeva M.Y. Modification of indices of human functional state under low-intensity electromagnetic radiation of very high frequency. Physics of the living, 2008, vol. 16, no. 1, pp. 91-98. (In Russ.)
5. Chuyan E.N., Ravaeva M.Yu. Mechanisms of action of low-intensity electromagnetic radiation of extremely high frequency on tissue microhemodynamics. In: Space and the biosphere. Abstracts of the XII International Crimean Conference dedicated to the 100th anniversary of the V.I. Vernadsky Crimean Federal University, the 120th anniversary of A.L. Chizhevsky, the 100th anniversary of V.A. Troitskaya and the 130th anniversary of P.M. Nagorsky", Alusta, 2017, pp. 158-162. (In Russ.)
6. Chuyan E.N., Ravaeva M.Y. Vasoprotective mechanisms of action of electromagnetic radiation of extremely high frequency in chronic hypokinetic stress. Journal Biomedical Radioelectronics, 2017, no. 3, pp. 55-65. (In Russ.)
7. Chuyan E.N., Ravaeva M.Y. The role of catecholamines in the regulation of tissue blood flow under the action of low-intensity electromagnetic radiation of extremely high frequency. Problems of Modern Science and Education, 2014, vol. 4, no. 22, pp. 13-18. (In Russ.)
8. Krupatkin A.I. Functional diagnostics of the state of microcirculatory and tissue systems: fluctuations, information, nonlinearity: guide for doctors. M.: Librocom, 2014, 498 p. (In Russ.)
9. Seregina E.S., Stelmaschuk O.A., Piavchenko G.A., Vorobyev E.V., Kuznetsova E.A., Alekseev A.G., Zherebtsov E.A., Journeymen K.V., Dunaev A.V. Evaluation of the effect of antioxidant substances on the metabolic processes of brain cells by fluorescence spectroscopy. Physics and Radio Electronics in Medicine and Ecology, 2018, no. 1, pp. 62-66. (In Russ.)
