Saint Petersburg, St. Petersburg, Russian Federation
Saint Petersburg, St. Petersburg, Russian Federation
Saint Petersburg, St. Petersburg, Russian Federation
Modern anticancer drugs have increased toxicity to the human body. There are also cases when tumor cells show resistance to certain classes of drugs. Therefore, the search and study of new compounds with antitumor properties remains an urgent task. In recent years, interest has arisen in the antioxidant and antitumor activity of catechins, which belong to plant flavonoids, and therefore their use in therapy, as well as their combined use with more toxic compounds, can reduce the negative impact of treatment on the body as a whole. Typically, antitumor activity is determined by the ability of compounds to bind to DNA. The paper studies the interaction of DNA with catechin in solution, and also considers the effect DNA of the simultaneous introduction of catechin and iron ions into the solution on DNA conformation. It has been shown that catechin molecules do not interact with DNA, while the presence of iron ions promotes the formation of DNA-catechin-iron complexes, in which catechin is expected to be able to exhibit its biological activity. The discrete nanoparticles are formed at sufficiently high concentrations of Fe3+ ions in catechin solutions. The methods used were UV spectrophotometry, low-gradient viscometry, dynamic light scattering, and atomic force microscopy.
(+)-catechin, DNA, iron ions (III), DNA-iron ions-catechin complexes
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