Abstract and keywords
Abstract (English):
In recent times, the field of medicine has witnessed a trend towards personalized medicine. The main difference of this approach compared to classical medicine is that your health is evaluated not based on average values of parameters from all individuals, but by tracking the dynamics of changes in your personal parameters. Developing new approaches to sample collection in order to enhance the attractiveness of medical testing plays an important role in the development of personalized medicine. In this regard, the needle-free venipuncture approach is gaining popularity. This method is based on laser ablation of the skin above the vein, followed by blood collection. This minimizes damage to surrounding tissues and reduces the formation of hematomas as a result of laser-induced melting at the boundaries of laser exposure. The main challenge in this approach is the ability to control the depth and radius of the resulting opening - the ability to obtain controlled openings in the skin using laser ablation. In the course of this study, a computer model of laser ablation was created for the studied objects using the COMSOL Multiphysics software. Additionally, an experimental setup was assembled using a Q-Switch Nd:YAG laser (Class D) for conducting experiments on multiple types of targets.

Keywords:
needleless venipuncture, laser ablation, skin
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References

1. Balter M.L., Leipheimer J.M., Chen A.I., Shrirao A., Maguire T.J., Yarmush M.L. Automated end-to-end blood testing at the point-of-care: Integration of robotic phlebotomy with downstream sample processing. Technology, 2018, vol. 06, iss. 02, pp. 59-66, doi:https://doi.org/10.1142/S2339547818500048.

2. Vogel A., Venugopalan V. Mechanisms of Pulsed Laser Ablation of Biological Tissues. Chem. Rev., 2003, vol. 103, iss. 2, pp. 577-644, doi:https://doi.org/10.1021/cr010379n.

3. Kono T., Ogawa N., Gonome H., Rajagopalan U.M., Yamada J. A local rapid temperature rise model for analyzing the effects of irradiation on human skin in laser treatments. International Journal of Heat and Mass Transfer, 2021, vol. 171, p. 121078, doi:https://doi.org/10.1016/j.ijheatmasstransfer.2021.121078.

4. Kurazumi Y., Rezgals L. Convective Heat Transfer Coefficients of the Human Body under Forced Convection from Ceiling. J Ergonomics, 2014, vol. 04, iss. 01, doi:https://doi.org/10.4172/2165-7556.1000126.

5. Firdous S. et al. Measurement of an Optical Parameters: Absorption Scattering and Auto-florescence of Skin in vitro. International J. of Cancer Research, 2004, vol. 1, iss. 1, pp. 10-15, doi:https://doi.org/10.3923/ijcr.2005.10.15.


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