Puebla, Mexico
Puebla, Mexico
Puebla, Mexico
Puebla, Mexico
Puebla, Mexico
Puebla, Mexico
Melatonin is synthesized mainly in the pineal gland, retina, digestive tract, and skin. This hormone is widely prescribed for therapeutic applications such as treating circadian rhythm, intercontinental flight dysrhythmia (jet lag syndrome), and sleep disorders. As a result of the COVID-19 pandemic, the consumption of this hormone was increased up to 300% in doses higher than 5 mg day because it was used to treat insomnia and as an adjunct to treat SARS-CoV-2. Therefore, this hormone is expected to be present in surface water bodies as a pollutant. Although it is reported that melatonin can be photolabile, its photochemistry has not been exhaustively studied. For this reason, the photodegradation of melatonin in solution was evaluated in this work. Solutions of 20 and 500 μM of melatonin dissolved in water were exposed to sunlight and UVA irradiation, and the degradation was monitored by spectrophotometry and total organic carbon.
melatonin, photodegradation, spectrophotometry, adjunct to treat SARS-CoV-2
1. Bell K.Y., Wells M.J.M., Traexler K.A., Pellegrin M.-L., Morse A., Bandy J. Emerging Pollutants. Water Environ Res., 2011, vol. 83, no.10, pp. 1906-1984.
2. Carballa M., Omil F., Lema J.M., Garc C., Rodr I. Behavior of pharmaceuticals , cosmetics and hormones in a sewage treatment plant. Water Res., 2004, vol. 38, pp. 2918-2926.
3. Macchi M.M., Bruce J.N. Human pineal physiology and functional significance of melatonin. Front Neuroendocrinol, 2004, vol. 25, no. 3-4, pp. 177-195.
4. Wichniak A., Kania A., Sieminski M., Cubala W.J. Review Melatonin as a Potential Adjuvant Treatment for COVID-19 beyond Sleep Disorders. Int J Mol Sci., 2021, vol. 22, pp. 1-14.
5. Ball A.T., Patel B.A. Rapid voltammetric monitoring of melatonin in the presence of tablet excipients. Electrochim Acta, 2012, vol. 83, pp. 196-201.
6. Li J., Somers V.K., Xu H., Lopez-Jimenez F., Covassin N. Trends in Use of Melatonin Supplements Among US Adults 1999-2018. 2022, vol. 327, no. 5, pp. 483-485.
7. Kuehn B.M. News From the Centers for Disease Control and Prevention. J Am Med Assoc., 2022, vol. 328, no. 2, p. 123.
8. Luboshitzky R., Shen-Orr Z., Nave R., Lavi S., Lavie P. Melatonin Administration Alters Semen Quality in Healthy Men. J Androl., 2002, vol. 23, no. 4, pp. 572-578.
9. Yilmaz B., Kutlu S., Mogulkuc R. et al. Melatonin inhibits testosterone secretion by acting at hypothalamo-pituitary-gonadal axis in the rat. Neuroendocr Lett., 2000, vol. 21, no. 4, pp. 301-306.
10. Speight J.G. Chemical Transformations in the Environment. In: Environmental Organic Chemistry for Engineers, 2017, pp. 305-350.
11. Daescu M., Toulbe N., Baibarac M., Mogos A., Lórinczi A., Logofatu C. Photoluminescence as a Complementary Tool for UV-VIS Spectroscopy to Highlight the Photodegradation of Drugs : A Case Study on Melatonin. Molecules, 2020, vol. 25, no. 3820, pp. 1-15.
12. Andrisano V., Bertucci C., Battaglia A., Cavrini V. Photostability of drugs : photodegradation of melatonin and its determination in commercial formulations. J Pharm Biomed Anal., 2000, vol. 23, pp. 15-23.
