Activity of free radical processes in patients with first episod of schizophrenia

T G Shcherbatyuk; A A Lyakhova; E S Zhukova; T V Zhilyaeva; A S Pyatyakina; I V Semennov; A L Tsvet; A B Gapeyev

UDC

577

ACTIVITY OF FREE RADICAL PROCESSES IN PATIENTS WITH FIRST EPISOD OF SCHIZOPHRENIA Activity of free radical processes in patients with first episod of schizophrenia

АА Аа

Published in Russian Journal of Biological Physics and Chemisrty · Pages 474–480 · Rubric: MEDICAL BIOPHYSICS AND BIOPHYSICAL CHEMISTRY

Received: 20.09.2020 Accepted: 20.09.2020 Published: 25.09.2020 Language of publication: RUS

Authors

T G Shcherbatyuk

A A Lyakhova

E S Zhukova

T V Zhilyaeva

A S Pyatyakina

I V Semennov

A L Tsvet

A B Gapeyev

T G Shcherbatyuk

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology; Pushchino State Institute of Natural Science; Moscow State Regional University

A A Lyakhova

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation

E S Zhukova

Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology

T V Zhilyaeva

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation

A S Pyatyakina

Clinical Psychiatric Hospital No. 1

I V Semennov

Clinical Psychiatric Hospital No. 1

A L Tsvet

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation

A B Gapeyev

Moscow State Regional University; Institute of Cell Biophysics of the Russian Academy of Sciences

ABSTRACT

Schizophrenia is by far the most common mental illness. This mental disorder is considered a multifactorial pathology associated not only with a genetic predisposition and neurochemical defects, but also, presumably, with impaired free radical oxidation processes. Currently, in practical psychiatry, there are no generally accepted biochemical markers for assessing the oxidative status of patients with schizophrenia. The article presents the results of a study of the activity of free radical oxidation processes in 20 patients with the first episodes of schizophrenia. The activity of spontaneous and metal-catalyzed oxidation of blood plasma proteins was evaluated, the degree of activity of superoxide dismutase and catalase in red blood cells was determined, and the level of glutathione in blood plasma was estimated. All patients, regardless of gender and age, showed a statistically significant increase in the degree of metal-catalyzed oxidation of plasma proteins and a decrease in the activity of superoxide dismutase and catalase. In male patients, a significantly reduced level of glutathione in plasma was recorded in comparison with the control group. Thus, the results obtained in patients with the first episodes of schizophrenia showed the presence of oxidative stress, decreased reserve-adaptive capabilities of the body, and the weakening of the activity of enzymatic and non-enzymatic antioxidant defense systems.

KEYWORDS

schizophrenia, oxidative stress, oxidative protein modification, superoxide dismutase, catalase, glutathione

Funding

Rabota vypolnena pri podderzhke granta RFFI 19-015-00420 (rukovoditel' Mazo G.E.).

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GOST

Shcherbatyuk T. G., Lyakhova A. A., Zhukova E. S., Zhilyaeva T. V., Pyatyakina A. S., Semennov I. V., Tsvet A. L., Gapeyev A. B. Activity of free radical processes in patients with first episod of schizophrenia // . 2020. pp. 474-480. (Date of access 19.08.2026).

MLA

T G Shcherbatyuk, Lyakhova A. A., Zhukova E. S., Zhilyaeva T. V., Pyatyakina A. S., Semennov I. V., Tsvet A. L., Gapeyev A. B.. "Activity of free radical processes in patients with first episod of schizophrenia." (2020): 474-480.

APA

Shcherbatyuk T. G., Lyakhova A. A., Zhukova E. S., Zhilyaeva T. V., Pyatyakina A. S., Semennov I. V., Tsvet A. L., Gapeyev A. B. (2020). Activity of free radical processes in patients with first episod of schizophrenia. , 474-480.

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{{cite journal | author = Shcherbatyuk T. G., Lyakhova A. A., Zhukova E. S., Zhilyaeva T. V., Pyatyakina A. S., Semennov I. V., Tsvet A. L., Gapeyev A. B. | title = Activity of free radical processes in patients with first episod of schizophrenia | journal = | year = 2020 | pages = 474-480 }}

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ACTIVITY OF FREE RADICAL PROCESSES IN PATIENTS WITH FIRST EPISOD OF SCHIZOPHRENIA Activity of free radical processes in patients with first episod of schizophrenia

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