Fatty acid composition and activity of antioxidant enzyms in rat tissues during tumor growth under ozone exposur

T P Kulagina; A B Gapeyev; A V Aripovsky; E. Zhukova; T G Shcherbatyuk

UDC

577

FATTY ACID COMPOSITION AND ACTIVITY OF ANTIOXIDANT ENZYMS IN RAT TISSUES DURING TUMOR GROWTH UNDER OZONE EXPOSUR Fatty acid composition and activity of antioxidant enzyms in rat tissues during tumor growth under ozone exposur

АА Аа

Published in Russian Journal of Biological Physics and Chemisrty · Pages 482–486 · Rubric: MEDICAL BIOPHYSICS AND BIOPHYSICAL CHEMISTRY

Received: 20.09.2021 Accepted: 20.09.2021 Published: 25.09.2021 Language of publication: RUS

Authors

T P Kulagina

A B Gapeyev

A V Aripovsky

E. Zhukova

T G Shcherbatyuk

T P Kulagina

Institute of Cell Biophysics of the Russian Academy of Sciences

A B Gapeyev

Institute of Cell Biophysics of the Russian Academy of Sciences; Moscow State Regional University

A V Aripovsky

Research and production company “A-Bio”

E. Zhukova

Nizhny Novgorod Scientific Research Institute for Hygiene and Occupational Pathology Russian Federation · Nizhny Novgorod

T G Shcherbatyuk

Moscow State Regional University; Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology; Pushchino State Institute of Natural Sciences

ABSTRACT

The effect of ozonized saline solution (OSS) with an ozone concentration in an ozone-oxygen mixture of 400 μg/L, administered intraperitoneally to male Sprague Dawley rats, on the fatty acid composition of the blood plasma, liver, and solid PC-1 liver carcinoma were studied. It was found that in the blood plasma of tumor-bearing rats, the amount of docosahexaenoic acid increased, accompanied by a decrease in the amount of palmitic and palmitoleic acids. After exposure of tumor-bearing rats to OSS, the amount of docosahexaenoic acid decreased to the level of intact animals. There were no changes in the amount of FAs in the liver and tumor tissue in any variant of the study. The tumor decreased an activity of catalase in the liver of animals. Exposure to OSS led to an even greater decrease in catalase activity in the liver of intact animals and tumor carriers. It is assumed that the exposure to OSS, as well as the tumor growth, trigger stress-induced tissue-specific free radical reactions in the body of rats, which depend on the type of tumor and the stage of tumor growth. The data obtained indicate the need for the correct dosage of OSS to control the intensity and direction of oxidative processes during tumor growth.

KEYWORDS

liver carcinoma, ozone, ozonized saline solution, fatty acids, superoxide dismutase, catalase

Funding

Rabota vypolnena pri finansovoy podderzhke Rossiyskogo fonda fundamental'nyh issledovaniy v ramkah proekta 19-02-00667.

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This work is licensed under Creative Commons Attribution 4.0 International Creative Commons

GOST

Kulagina T. P., Gapeyev A. B., Aripovsky A. V., Zhukova E. S., Shcherbatyuk T. G. Fatty acid composition and activity of antioxidant enzyms in rat tissues during tumor growth under ozone exposur // . 2021. pp. 482-486. (Date of access 19.08.2026).

MLA

T P Kulagina, Gapeyev A. B., Aripovsky A. V., Zhukova E. S., Shcherbatyuk T. G.. "Fatty acid composition and activity of antioxidant enzyms in rat tissues during tumor growth under ozone exposur." (2021): 482-486.

APA

Kulagina T. P., Gapeyev A. B., Aripovsky A. V., Zhukova E. S., Shcherbatyuk T. G. (2021). Fatty acid composition and activity of antioxidant enzyms in rat tissues during tumor growth under ozone exposur. , 482-486.

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{{cite journal | author = Kulagina T. P., Gapeyev A. B., Aripovsky A. V., Zhukova E. S., Shcherbatyuk T. G. | title = Fatty acid composition and activity of antioxidant enzyms in rat tissues during tumor growth under ozone exposur | journal = | year = 2021 | pages = 482-486 }}

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FATTY ACID COMPOSITION AND ACTIVITY OF ANTIOXIDANT ENZYMS IN RAT TISSUES DURING TUMOR GROWTH UNDER OZONE EXPOSUR Fatty acid composition and activity of antioxidant enzyms in rat tissues during tumor growth under ozone exposur

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