ABOUT INFORMATIONAL OPPORTUNITIES AND RESULTS OF EXPERIMENTAL STUDIES  OF GDV VISUALIZATION PROTEIN-INDUCED MOLECULAR COMPLEXES IN AQUEOUS SOLUTIONS OF TABLETS, CONTAINING ANTIBODIES TO INTERFERON-γ

O. Maslennikova; A. Sibirev; M. Shipko; M. Stepovich

doi:10.29039/rusjbpc.2023.0593

ABOUT INFORMATIONAL OPPORTUNITIES AND RESULTS OF EXPERIMENTAL STUDIES OF GDV VISUALIZATION PROTEIN-INDUCED MOLECULAR COMPLEXES IN AQUEOUS SOLUTIONS OF TABLETS, CONTAINING ANTIBODIES TO INTERFERON-Γ ABOUT INFORMATIONAL OPPORTUNITIES AND RESULTS OF EXPERIMENTAL STUDIES OF GDV VISUALIZATION PROTEIN-INDUCED MOLECULAR COMPLEXES IN AQUEOUS SOLUTIONS OF TABLETS, CONTAINING ANTIBODIES TO INTERFERON-γ

АА Аа

Published in Russian Journal of Biological Physics and Chemisrty · Pages 84–88 · Rubric: MEDICAL BIOPHYSICS AND BIOPHYSICAL CHEMISTRY

DOI: https://doi.org/10.29039/rusjbpc.2023.0593

Received: 10.07.2023 Accepted: 16.05.2024 Published: 16.05.2024

Authors

O. Maslennikova

A. Sibirev

M. Shipko

M. Stepovich

O. Maslennikova

Central State Medical Academy of Department of Presidential Affairs Russian Federation · Moscow

A. Sibirev

Lenin Ivanovo State Power Engineering University Russian Federation · Ivanovo

M. Shipko

Lenin Ivanovo State Power Engineering University Russian Federation · Ivanovo

M. Stepovich

Tsiolkovsky Kaluga State University Russian Federation · Kaluga

ABSTRACT

The character of changes in the positional order in the arrangement of protein-induced water associates in aqueous solutions of tableted drugs containing antibodies to interferon-γ was studied by the method of gas-discharge visualization. As objects of study, we used aqueous solutions of tablet forms, which were obtained by applying antibody solutions (with a concentration of 10–24 mg/ml) onto a carrier (89% raw lactose, 10% microcrystalline cellulose, 1% magnesium stearate). The informative possibilities of the gas-discharge visualization method in the analysis of data on the entropy, fractality, and length of emission isolines caused by kilovolt electrons released from aqueous solutions of tablet preparations containing antibodies to interferon-γ are considered. It has been shown that the activation of solutions by antibodies to interferon-γ is associated with the intensification of associative processes accompanied by the ordering of protein-induced molecular complexes. In general, the obtained results indicate the preservation of water associates formed in the process of ultrahigh dilution in solutions of tableted samples with antibodies to interferon.

KEYWORDS

gas discharge imaging, antibodies to interferon-γ, ultra-low concentration, water associates

Funding

Issledovanie vypolneno za schet granta Rossiyskogo nauchnogo fonda i Pravitel'stva Kaluzhskoy oblasti № 23-21-10069, https://rscf.ru/project/23-21-10069/, https://rscf.ru/en/project/23-21-10069/.

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Dmitriy Voronin

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Chief Editor

Maksim Evstigneev

Science Editor

Vsevolod A. Tverdislov

tverdislov@mail.ru

This work is licensed under Creative Commons Attribution 4.0 International Creative Commons

GOST

Maslennikova O. M., Sibirev A. L., Shipko M. N., Stepovich M. A. ABOUT INFORMATIONAL OPPORTUNITIES AND RESULTS OF EXPERIMENTAL STUDIES OF GDV VISUALIZATION PROTEIN-INDUCED MOLECULAR COMPLEXES IN AQUEOUS SOLUTIONS OF TABLETS, CONTAINING ANTIBODIES TO INTERFERON-γ // . 2024. pp. 84-88. DOI: https://doi.org/10.29039/rusjbpc.2023.0593. (Date of access 19.08.2026).

MLA

O. Maslennikova, Sibirev A. L., Shipko M. N., Stepovich M. A.. "ABOUT INFORMATIONAL OPPORTUNITIES AND RESULTS OF EXPERIMENTAL STUDIES OF GDV VISUALIZATION PROTEIN-INDUCED MOLECULAR COMPLEXES IN AQUEOUS SOLUTIONS OF TABLETS, CONTAINING ANTIBODIES TO INTERFERON-γ." (2024): 84-88. DOI: https://doi.org/10.29039/rusjbpc.2023.0593.

APA

Maslennikova O. M., Sibirev A. L., Shipko M. N., Stepovich M. A. (2024). ABOUT INFORMATIONAL OPPORTUNITIES AND RESULTS OF EXPERIMENTAL STUDIES OF GDV VISUALIZATION PROTEIN-INDUCED MOLECULAR COMPLEXES IN AQUEOUS SOLUTIONS OF TABLETS, CONTAINING ANTIBODIES TO INTERFERON-γ. , 84-88. https://doi.org/10.29039/rusjbpc.2023.0593

Chicago

O. Maslennikova, Sibirev A. L., Shipko M. N., Stepovich M. A.. "ABOUT INFORMATIONAL OPPORTUNITIES AND RESULTS OF EXPERIMENTAL STUDIES OF GDV VISUALIZATION PROTEIN-INDUCED MOLECULAR COMPLEXES IN AQUEOUS SOLUTIONS OF TABLETS, CONTAINING ANTIBODIES TO INTERFERON-γ." , no. (2024): 84-88. https://doi.org/10.29039/rusjbpc.2023.0593.

WIKI

{{cite journal | author = Maslennikova O. M., Sibirev A. L., Shipko M. N., Stepovich M. A. | title = ABOUT INFORMATIONAL OPPORTUNITIES AND RESULTS OF EXPERIMENTAL STUDIES OF GDV VISUALIZATION PROTEIN-INDUCED MOLECULAR COMPLEXES IN AQUEOUS SOLUTIONS OF TABLETS, CONTAINING ANTIBODIES TO INTERFERON-γ | journal = | year = 2024 | pages = 84-88 | doi = 10.29039/rusjbpc.2023.0593 }}

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