NON-STEROID ANTI-INFLAMMATORY DRUG MELOXICAM ATTENUATES THE EFFECT OF IMMUNOMODULATOR GLUTOXIM ON Na+ TRANSPORT   IN FROG SKIN EPITHELIUM

A. Melnitskaya; Z. Krutetskaya; V. Antonov; N. Krutetskaya; V. Badulina

doi:10.29039/rusjbpc.2023.0628

NON-STEROID ANTI-INFLAMMATORY DRUG MELOXICAM ATTENUATES THE EFFECT OF IMMUNOMODULATOR GLUTOXIM ON NA+ TRANSPORT IN FROG SKIN EPITHELIUM NON-STEROID ANTI-INFLAMMATORY DRUG MELOXICAM ATTENUATES THE EFFECT OF IMMUNOMODULATOR GLUTOXIM ON Na+ TRANSPORT IN FROG SKIN EPITHELIUM

АА Аа

Published in Russian Journal of Biological Physics and Chemisrty · Pages 328–332 · Rubric: MEDICAL BIOPHYSICS AND BIOPHYSICAL CHEMISTRY

DOI: https://doi.org/10.29039/rusjbpc.2023.0628

Received: 20.07.2023 Accepted: 27.05.2024 Published: 27.05.2024

Authors

A. Melnitskaya

Z. Krutetskaya

V. Antonov

N. Krutetskaya

V. Badulina

A. Melnitskaya

Saint-Petersburg State University Russian Federation · Saint Petersburg

Z. Krutetskaya

Saint-Petersburg State University Russian Federation · Saint Petersburg

V. Antonov

Saint-Petersburg State Pediatric Medical University Russian Federation · Saint Petersburg

N. Krutetskaya

Saint-Petersburg State University Russian Federation · Saint Petersburg

V. Badulina

Saint-Petersburg State University Russian Federation · Saint Petersburg

ABSTRACT

The article is devoted to the study of redox regulation of transepithelial ion transport in osmoregulatory epithelium. The pharmacological analogue of oxidized glutathione, drug glutoxim®, has antioxidant and radioprotective properties and is widely used as an immunomodulator and cytoprotector in complex therapy of bacterial, viral and oncological diseases. Using voltage-clamp technique, the influence of non-steroidal anti-inflammatory drug meloxicam, an inhibitor of the cyclooxygenase pathway of arachidonic acid oxidation, on glutoxim effect on Na+ transport in frog Rana temporaria skin was investigated. It was shown for the first time that frog skin preincubation with meloxicam significantly reduces the stimulatory effect of glutoxim on Na+ transport. The data obtained indicate the involvement of cyclooxygenase pathway of arachidonic acid oxidation in the effect of glutoxim on Na+ transport in frog skin epithelium. The results also contribute to a more detailed understanding of molecular mechanisms of pharmacological effect of glutoxim and meloxicam, and may be useful for their application in clinics.

KEYWORDS

Na+ transport, glutoxim, meloxicam, frog skin epithelium

Funding

Rabota vypolnena v ramkah planovyh tem Kafedry biofiziki Sankt-Peterburgskogo gosudarstvennogo universiteta i Kafedry biohimii Sankt-Peterburgskogo gosudarstvennogo pediatricheskogo medicinskogo universiteta, a takzhe Dogovora na vypolnenie nauchno-issledovatel'skih rabot № 05/03-20.

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Dmitriy Voronin

dpvoronin@sevsu.ru

Chief Editor

Maksim Evstigneev

Science Editor

Vsevolod A. Tverdislov

tverdislov@mail.ru

This work is licensed under Creative Commons Attribution 4.0 International Creative Commons

GOST

Melnitskaya A. V., Krutetskaya Z. I., Antonov V. G., Krutetskaya N. I., Badulina V. I. NON-STEROID ANTI-INFLAMMATORY DRUG MELOXICAM ATTENUATES THE EFFECT OF IMMUNOMODULATOR GLUTOXIM ON Na+ TRANSPORT IN FROG SKIN EPITHELIUM // . 2024. pp. 328-332. DOI: https://doi.org/10.29039/rusjbpc.2023.0628. (Date of access 20.08.2026).

MLA

A. Melnitskaya, Krutetskaya Z. I., Antonov V. G., Krutetskaya N. I., Badulina V. I.. "NON-STEROID ANTI-INFLAMMATORY DRUG MELOXICAM ATTENUATES THE EFFECT OF IMMUNOMODULATOR GLUTOXIM ON Na+ TRANSPORT IN FROG SKIN EPITHELIUM." (2024): 328-332. DOI: https://doi.org/10.29039/rusjbpc.2023.0628.

APA

Melnitskaya A. V., Krutetskaya Z. I., Antonov V. G., Krutetskaya N. I., Badulina V. I. (2024). NON-STEROID ANTI-INFLAMMATORY DRUG MELOXICAM ATTENUATES THE EFFECT OF IMMUNOMODULATOR GLUTOXIM ON Na+ TRANSPORT IN FROG SKIN EPITHELIUM. , 328-332. https://doi.org/10.29039/rusjbpc.2023.0628

Chicago

A. Melnitskaya, Krutetskaya Z. I., Antonov V. G., Krutetskaya N. I., Badulina V. I.. "NON-STEROID ANTI-INFLAMMATORY DRUG MELOXICAM ATTENUATES THE EFFECT OF IMMUNOMODULATOR GLUTOXIM ON Na+ TRANSPORT IN FROG SKIN EPITHELIUM." , no. (2024): 328-332. https://doi.org/10.29039/rusjbpc.2023.0628.

WIKI

{{cite journal | author = Melnitskaya A. V., Krutetskaya Z. I., Antonov V. G., Krutetskaya N. I., Badulina V. I. | title = NON-STEROID ANTI-INFLAMMATORY DRUG MELOXICAM ATTENUATES THE EFFECT OF IMMUNOMODULATOR GLUTOXIM ON Na+ TRANSPORT IN FROG SKIN EPITHELIUM | journal = | year = 2024 | pages = 328-332 | doi = 10.29039/rusjbpc.2023.0628 }}

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NON-STEROID ANTI-INFLAMMATORY DRUG MELOXICAM ATTENUATES THE EFFECT OF IMMUNOMODULATOR GLUTOXIM ON NA+ TRANSPORT IN FROG SKIN EPITHELIUM NON-STEROID ANTI-INFLAMMATORY DRUG MELOXICAM ATTENUATES THE EFFECT OF IMMUNOMODULATOR GLUTOXIM ON Na+ TRANSPORT IN FROG SKIN EPITHELIUM

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