UDC 577

BIOFUNCTIONAL ALIPHATIC POLYESTER-BASED PARTICLES - PERSPECTIVE DRUG DELIVERY SYSTEMS

Published in Russian Journal of Biological Physics and Chemisrty · Volume 1, Issue 2 · Pages 206–210 · Rubric: BIOORGANIC, BIOPHYSICAL AND MEDICINAL CHEMISTRY
Received: 20.12.2016 Accepted: 20.12.2016 Published: 25.12.2016 Language of publication: RUS
The paper describes the basic principles as applied to create polymeric micro- and nanoparticles to deliver both low molecular weight and high molecular weight drugs into the body. For micro- and nanoparticles obtaining the methods of single emulsion and nanoprecipitation were used, respectively. We used single emulsion method to encapsulate hydrophobic drugs the, and double emulsion method to include hydrophilic molecules and proteins. Furthermore, results of biological tests of the obtained polymer particles for therapy of tuberculosis are presented.
biodegradable particles, drug delivery systems
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