UDC
577

MODELING THE STACKING INTERACTIONS OF FLAVIN-MONONUCLEOTIDE WITH THE NITROGENOUS BASES OF DNA

Published in Russian Journal of Biological Physics and Chemisrty · Pages 320–326 · Rubric: Modelling in biophycis
Received: 20.06.2018 Accepted: 20.06.2018 Published: 25.06.2018 Language of publication: RUS
Authors
The mechanism of the interaction flavin-mononucleotide (FMN) with bases DNA and with fragment DNA were explored. The most probable structures complex FMN with bases, with pair of the bases and with fragment DNA have been calculated by means of semi- and nonempirical methods. Structures and thermodynamic parameters of complex FMN with pair of the bases DNA have been determined. The contribution of different physical-chemical forces of the interaction in stabilization complexes of molecules has been installed. Сonclusion about molecular mechanism of the interaction FMN with bases DNA has been made.
flavin-mononucleotide, bases DNK, semi- and nonempirical methods, dispersion interaction, intercalation
Text References
Text (PDF)
Read Download

1. Davies D.B., Veselkov D.A., Djimant L.N., Veselkov A.N. Hetero-association of caffeine and aromatic drugs and their competitive binding with a DNA oligomer. Eur. Biophys. J., 2001, vol. 30, pp. 354-366. DOI: https://doi.org/10.1007/s002490100150; EDN: https://elibrary.ru/XOQIKN

2. Lubas B., Soltysik M. Proton NMR study of the interaction of riboflavin with the egg-yolk apoprotein. FEBS Letters., 1977, vol. 79, no. 1, pp. 179-182.

3. Monaco H.L. Crystal structure of chicken riboflavin-binding protein. EMBO J., 1997, vol. 16, no. 7, pp. 1475-1483.