SYMMETRY BREAKING IS THE PHYSICAL BASIS FOR THE PERFORMANCE OF "USEFUL WORK" BY BIOLOGICAL MOLECULAR MACHINES

Vsevolod A. Tverdislov

doi:10.29039/rusjbpc.2022.0559

UDC 577

SYMMETRY BREAKING IS THE PHYSICAL BASIS FOR THE PERFORMANCE OF "USEFUL WORK" BY BIOLOGICAL MOLECULAR MACHINES

Published in Russian Journal of Biological Physics and Chemisrty · Volume 7, Issue 4 · Pages 552–556 · Rubric: General biophysics

DOI: https://doi.org/10.29039/rusjbpc.2022.0559

Received: 09.08.2022 Accepted: 24.11.2022 Published: 24.11.2022

Authors

Vsevolod A. Tverdislov

Academic degree: doctor of physical and mathematical sciences

Science rang: professor

Lomonosov Moscow State University Head of the Department · Department of Biophysics, Faculty of Physics · Russian Federation · Moscow

ABSTRACT

The physical basis for the functioning of living systems are molecular machines. The performance of "useful work" is the essence of their biological functions. Molecular machines are chiral hierarchically organized devices (constructions). They cyclically transform the form of energy by changing or switching symmetries in its chiral structural elements, which just realize the selected “quasi-mechanical” degrees of freedom in them. The phenomenon of chirality allows the formation of discrete chirally sign-alternating hierarchies of structures in macromolecular machines in the process of folding: starting from the level of asymmetric carbon in deoxyribose and amino acids. Previously, we have identified and analyzed the tendency of alternation of the sign of chirality of the intramolecular structural levels D-L-D-L for DNA and L-D-L-D for proteins. Helicity and superhelicity of intramolecular and supramolecular structures are also manifestations of chirality. Also, within the framework of the developed ideas, the chiral splitting of the properties of the elements of the structures ensures the unidirectional movement of machines along the energy cycle due to the nonlinear valve properties of the spiral structures. Spiral structures can serve as asymmetric, non-linear, mechanical, including switching, structural elements of molecular machines (like a ratchet-pawl device) in terms of rotational degrees of freedom.

KEYWORDS

molecular machines, proteins, thermodynamics, symmetries, chirality, self-organization, nonlinearity, folding, helices, supercoils, ventilarity

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GOST

Tverdislov V. A. SYMMETRY BREAKING IS THE PHYSICAL BASIS FOR THE PERFORMANCE OF "USEFUL WORK" BY BIOLOGICAL MOLECULAR MACHINES // Russian Journal of Biological Physics and Chemisrty. 2022. no. 4. pp. 552-556. DOI: https://doi.org/10.29039/rusjbpc.2022.0559. (Date of access 15.10.2026).

MLA

Vsevolod A. Tverdislov. "SYMMETRY BREAKING IS THE PHYSICAL BASIS FOR THE PERFORMANCE OF "USEFUL WORK" BY BIOLOGICAL MOLECULAR MACHINES." Russian Journal of Biological Physics and Chemisrty 7.4 (2022): 552-556. DOI: https://doi.org/10.29039/rusjbpc.2022.0559.

APA

Tverdislov V. A. (2022). SYMMETRY BREAKING IS THE PHYSICAL BASIS FOR THE PERFORMANCE OF "USEFUL WORK" BY BIOLOGICAL MOLECULAR MACHINES. Russian Journal of Biological Physics and Chemisrty, 7(4), 552-556. https://doi.org/10.29039/rusjbpc.2022.0559

Chicago

Vsevolod A. Tverdislov. "SYMMETRY BREAKING IS THE PHYSICAL BASIS FOR THE PERFORMANCE OF "USEFUL WORK" BY BIOLOGICAL MOLECULAR MACHINES." Russian Journal of Biological Physics and Chemisrty 7, no. 4 (2022): 552-556. https://doi.org/10.29039/rusjbpc.2022.0559.

WIKI

{{cite journal | author = Tverdislov V. A. | title = SYMMETRY BREAKING IS THE PHYSICAL BASIS FOR THE PERFORMANCE OF "USEFUL WORK" BY BIOLOGICAL MOLECULAR MACHINES | journal = Russian Journal of Biological Physics and Chemisrty | year = 2022 | volume = 7 | issue = 4 | pages = 552-556 | doi = 10.29039/rusjbpc.2022.0559 }}

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