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Russian Journal of Biological Physics and Chemisrty
Journals / Russian Journal of Biological Physics and Chemisrty / Volume 7 Issue 4 / NEW VARIANTS OF DINITROSYL IRON COMPLEXES. ANTIOXIDANT AND ANTIRADICAL EFFECT
UDC 577

NEW VARIANTS OF DINITROSYL IRON COMPLEXES. ANTIOXIDANT AND ANTIRADICAL EFFECT

Published in Russian Journal of Biological Physics and Chemisrty · Volume 7, Issue 4 · Pages 624–627 · Rubric: MEDICAL BIOPHYSICS AND BIOPHYSICAL CHEMISTRY
DOI: https://doi.org/10.29039/rusjbpc.2022.0572
Received: 01.08.2022 Accepted: 24.11.2022 Published: 24.11.2022
Authors
K.
K. Shumaev
O.
O. Kosmachevskaya
A.
A. Topunov
D.
D. Grachev
et al.
E.
E. Nasybullina
I.
I. Pugachenko
E.
E. Ruuge
ABSTRACT
Dinitrosyl iron complexes (DNICs) are important metabolites of nitric oxide (NO) with a wide range of biological activity. The properties of these complexes are determined not only by NO-ligands, but also by other components included in their composition. Using EPR spectroscopy, it was shown that iron in the DNICs can be bound to carnosine, L-ergothioneine and ADP. New variants of DNICs are formed with the participation of a nitroxyl anion, which is a product of one-electron reduction of NO. In model systems, DNICs associated with carnosine and ergothioneine reduce the level of various free radicals. These DNICs intercept the superoxide anion radical, which is a precursor to other reactive oxygen and nitrogen species. At the same time, carnosine-bound DNICs reduce the concentration of organic free radicals in a system containing a nitroxyl anion, iron ions and tert-butyl hydroperoxide. On the other hand, DNICs associated with ergothioneine and ADP may play an important role in the protection of mitochondria. It has been suggested that the new DNICs may be components of antioxidant systems localized in various tissues of the body, as well as redox triggers regulating the cellular response to oxidative stress.
KEYWORDS
dinitrosyl iron complexes, nitric oxide, free radical, EPR spectroscopy
Funding
Rabota vypolnena pri finansovoy podderzhke Rossiyskogo Fonda Fundamental'nyh Issledovaniy (grant № 19-29-12052) i Ministerstva nauki i vysshego obrazovaniya Rossiyskoy Federacii.
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