Создание новых функциональных биосовместимых и биоактивных материалов и эффективных систем для капсулирования, адресной доставки и управляемого высвобождения различных веществ в водных средах, в том числе в живых системах, является в настоящее время актуальной задачей биологической физики и химии, а также ряда смежных областей, решение которой важно для практических биомедицинских применений. В данной работе нами получены и охарактеризованы новые нанокомпозитные биомиметические функциональные наносистемы на основе пленок Ленгмюра-Блоджетт, а также везикулы и капсулы на основе мембранных комплексов, включающих липиды, функциональные аминосодержащие амфифильные соединения, полимеры (в том числе биополимеры) и функциональные неорганические наночастицы (Fe3O4 и Au). Исследования проводились методами просвечивающей электронной микроскопии, атомно-силовой микроскопии, электронного парамагнитного резонанса.
биомиметические наноструктуры, липосомы, ДНК, наночастицы магнетита
1. Freeman A.I., Mayhew E. Targeted drug delivery. Cancer, 1986, vol. 58, pp. 573-583.
2. Svenson S., Robert K. Multifunctional Nanoparticles for Drug Delivery Applications: Imaging, Targeting, and Delivery Series. Nanostructure Science and Technology, Springer, 2012, 373p.
3. Parveen S., Misra R., Sahoo S.K. Nanoparticles: a boon to drug delivery, therapeutics, diagnostics and imaging. Nanomedicine: Nanotechnology, Biology and Medicine, 2012, vol. 8, no. 2, pp. 147-166.
4. Kataokaa K., Haradaa A., Nagasaki Y. Block copolymer micelles for drug delivery: design, characterization and biological significance. Advanced Drug Delivery Reviews, 2001, vol. 47, no. 1, pp. 113-131.
5. Donath E., Sukhorukov G.B., Caruso F., Devis S.A., Möhwald H. Novel Hollow Polymer Shells by Colloid- Templated Assembly of Polyelectrolytes. Angew Chem. Int. Ed. Engl., 1998, vol. 37, 2202 p.
6. Sukhorukov G.B., Donath E., Davis S.A., Lichtenfeld A., Caruso F., Popov V.I., Möhwald H. Stepwise polyelectrolyte assembly on particle surfaces: A Novel Approach to Colloid Design. Polym. Adv. Technol., 1998, vol. 9, 759 p.
7. Radtchenko I.L., Sukhorukov G.B., Leporatti S., Khomutov G.B., Donath E., Mohwald H. Assembly of alternated multivalent ion/polyelectrolyte layers on colloidal particles. Stability of the multilayers and encapsulation of macromolecules into polyelectrolyte capsules. J. Colloid. Interface Sci., 2000, vol. 230, no. 2, pp. 272-280.
8. Sukhorukov G.B., Antipov A., Voigt A., Donath E., Möhwald H. pH-Controlled Macromolecule Encapsulation in and Release from Polyelectrolyte Multilayer Nanocapsules. Macromol. Rapid Commun, 2001, vol. 22, pp. 44-46.
9. Skirtach A.G., Antipov A.A., Shchukin D.G., Sukhorukov G.B. Remote activation of capsules containing Ag nanoparticles and IR dye by laser light. Langmuir, 2004, vol. 20, pp. 6988-6992.
10. Radt B., Smith T.A., Caruso F. Optically Addressable Nanostructured Capsules. Adv. Mater, 2004, vol. 16, pp. 2184-2189.
11. Lu Z., Prouty M.D., Guo Z., Golub V.O., Kumar C.S.S.R., Lvov Y.M. Magnetic switch of permeability for polyelectrolyte microcapsules embedded with Co, Au nanoparticles. Langmuir, 2005, vol. 21, pp. 2042-2050.
12. Gorin D.A., Shchukin D.G., Mikhailov A.I., Kohler K., Sergeev S.A., Portnov S.A., Taranov I.V., Kislov V.V., Sukhorukov G.B. Effect of Microwave Radiation on Polymer Microcapsules Containing Inorganic Nanoparticles. Technical Physics Letters, 2006, vol. 32, no. 1, pp. 70-72.
13. Gorin D.A., Shchukin D.G., Koksharov Yu.A., Portnov S.A., Köhler K., Taranov I.V., Kislov V.V., Khomutov G.B., Möhwald H., Sukhorukov G.B. Effect of microwave irradiation on composite iron oxide nanoparticle/polymer microcapsules. Proceedings of SPIE, 2007, vol.6536, no. 653604.
14. Schwendener R.A. Liposomes in biology and medicine. Adv. Exp. Med. Biol., 2007, vol. 620, pp. 117-28.
15. Lasic D.D. Liposomes: from physics to applications. Elsevier, Amsterdam, New York, 1993, 575 p.
16. Wagner A., Vorauer-Uhl K Liposome Technology for Industrial Purposes. Journal of Drug Delivery, 2011, article ID 591325, 9 p.
17. Koning G.A, Eggermont A.M., Lindner L.H., ten Hagen T.L.M. Hyperthermia and Thermosensitive Liposomes for Improved Delivery of Chemotherapeutic Drugs to Solid Tumors. Springer Pharm Res., 2010, pp. 1750-1754.
18. Ranganathan1 R., Madanmohan S., Kesavan A., Baskar G., Ramia Y., Krishnamoorthy, Santosham R., Ponraju D., Rayala S.K., Venkatraman G. Nanomedicine towards development of patient-friendly drug-delivery systems for oncological applications. International Journal of Nanomecine, 2012, pp. 1043-1060.
19. Glaser R.W., Leikin S.L., Chernomordik L.V., Pastushenko V.F., Sokirko A.I. Reversible electrical breakdown of lipid bilayers - formation and evolution of pores. Biochimica Et Biophysica Acta, 1988, vol. 940, pp. 275-287.
20. Weaver J.C., Chizmadzhev Y. Theory of electroporation. A review. Bioelectroch Bioener, 1996, vol. 41, pp. 135-160.
21. Widder K.J., Senyei A.E., Scarpelli D.G. Magnetic microspheres:a model system for site specific drug delivery in vivo. Proc. Soc. Exp. Biol. Med., 1978, vol. 58, pp. 141-146.
22. Giersig M., Khomutov G.B. (editors) Nanomaterials for application in medicine and biology. Springer, Dordrecht, The Netherlands, 2008, 188 p.
23. Amstad E., Textor M., Reimhult E. Stabilization and functionalization of iron oxide nanoparticles for biomedical applications. Nanoscale, 2011, vol. 3, no. 7, pp. 2819-2843.
24. Gupta A.K., Gupta M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials, 2005, vol. 26, pp. 3995-4021.
25. Massart R. Preparation of aqueous magnetic liquids in alkaline and acidic media. IEEE Transactions on Magnetics, 1981, vol. 17, pp. 1247-1248.
26. Gulyaev Yu.V., Cherepenin V.A., Vdovin V.A. [et al.] Pulsed electric field-induced remote decapsulation of Nanocomposite liposomes with implanted conducting nanoparticles. Journal of communications technology and electronics, 2015, vol. 60, no. 10, pp. 1097-1108.
