In this work it is shown that breast cancer is a complex process, due to the large number of molecular factors (genes, receptors, enzymes, proteins, etc.) and environmental factors (tobacco, alcohol, radiation, lack of physical activity, obesity), therefore, an interdisciplinary approach is necessary. Two alternative ways of analyzing and understanding the physical-biological level of the disease are addressed: the experimental part and the theoretical part (theory of complex networks). The first part seeks to understand that the realization of the experiments although they are an important way of explaining how to process occurs (chemical-biological), these generate great costs and can take months or years to simply give us an answer with a reductionist approach. The second seeks to overcome the scheme that places genes and proteins as linear determinants of all phenotypes, to be considered in their global interactions through molecular processes of intracellular-extracellular self-organization, in order to understand systems in less time and with less cost, in addition to using an integrative and systemic approach. This research integrates sufficient evidence to corroborate that the genes are self-organized in these complex networks, whose hierarchical and modular structures allow us to understand the way in which a mutation or removal of specific genes (such as oncogenes and tumor suppressors) can alter global cellular behaviors (proliferation, migration, apoptosis, metastatic processes, etc.). In this sense, this work assumes the challenge of responding to academic, scientific and social needs; This work is intended to be a starting point for new research and to provide information that will help in the treatment and programs to fight against breast cancer .
Breast Cancer, Obesity, Leptin, ObR, Complex Networks
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