The combined effect of the antitumor antibiotic NOV and pristine fullerene on human buccal epithelial cells was studied. Assessment of the chromatin in the cells was evaluated by the number of heterochromatin granules (KGG) in the nuclei of cells after orsein staining. The cell suspension was treated with a solution of NOV at constant concentration and variable fullerene concentration. Under the combined action of DNA-intercalator novatrone on non- proliferating buccal epithelium cells a concentration-dependent restoration of the functional activity of the cell nucleus was observed on addition of pristine C60 fullerene.
C60 fullerene, human buccal epithelial cells, novatrone
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