Simple pharmacokinetic compartment model with absorption was analyzed in this paper. Impact of the processes of self- association of the active ingredient on the dynamics of the distribution and elimination of the drug was determined. The result of this research is one-compartment model with suction, which takes into account the process of self-association of the drug. This model is applied to describe the kinetics of doxorubicin distribution in the body. Decrease in concentration of the drug in the body considering self- association was found. This fact was caused by the low ability of the complexes to be absorbed in the body due to their significant size and stability.
one-compartment model, self- association, Doxorubicin
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