National Research Tomsk State University
Tomsk, Tomsk, Russian Federation
In our previous works, to model the dynamics of angular oscillations of the bases of the gene coding interferon alpha 17 (IFNA17), we used a quasi-homogeneous approach where parameters of the mathematical model were averaged over all length of the gene sequence. In this paper, we take into account the inhomogeneous character of the gene sequence which consists of three regions: the coding region (50..619) and the two regions (1..49 and 620..980) with unknown functional significance. We use the approach in which the parameters of the mathematical model are averaged separately over each of the three regions. This gave us a possibility to calculate the energy profile of the gene and to build the trajectory of DNA kink in the potential with the profile.
interferon, gene energy profile, trajectory of the DNA kink motion
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