Moscow, Moscow, Russian Federation
The binding of biologically active compounds with nucleic acids should be described using the models of physical adsorption. The application of the Ising model allows to formulate an analytical solution of the mathematical equations of adsorption in the most general terms for a wide class of models. The developed approaches are outlined in the monograph addressing the analysis of biologically active compounds binding to the nucleic acids.
DNA-ligand binding, cooperative interactions, binding curve, Ising model
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