A model for chiral periodicity with alternating chiral sense in hierarchies of protein and nucleic acid structures is proposed and substantiated. The model describes also chiral conformities in interactions of macromolecules of the same or different types. Regular alternation of the chirality sense is revealed in transitions from the lowest to higher levels of structural-functional organisation both in DNA molecules where it is D-L-D-L (the stucture of the deoxyribose polymeric chain is taken to be the primary structure), and in proteins where it is shifted in chiral phase to L-D-L-D. Such cross-chiral (antiphase) correspondence between proteins and DNAs forms the basic structural unit of molecular biology as an achiral invariant allowing to realise chiral motifs in the interactions of molecules of same or different classes through interactions of specific chemical groups. Prospects of practical application of the approach developed here is related to the modelling of the interaction of chiral drugs with macromolecular targets as well as with the selection of chiral cryoprotectants in the methods associated with the cryopreservation of biomaterials.
chirality, nucleic acids, proteins, structural hierarchies
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