![THE EFFECT OF WATER SOLUBLE F-828 [C60] FULLERENE DERIVATIVE ON PROLIFERATION AND CELL DEATH OF HUMAN EMBRYONIC LUNG FIBROBLASTS](/upload/21232f297a57a5a743894a0e4a801fc3/journals/cover/f8c56688fa307e98584d30b341015d28.jpeg)
Moscow, Moscow, Russian Federation
Federal Scientific and Clinical Center of Medical Rehabilitation and Balneology of the Federal Medical and Biological Agency of Russia
Moscow, Moscow, Russian Federation
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology
Moscow, Moscow, Russian Federation
Moscow, Moscow, Russian Federation
Moscow, Moscow, Russian Federation
Chernogolovka, Moscow, Russian Federation
Moscow, Moscow, Russian Federation
It is a matter of common knowledge that C60 fullerenes and their derivatives have antioxidant properties due to their chemical structure. Studies show that these substances also possess antiviral and anticancer activity, moreover, they are under studies as potential nanocarriers for drug delivery across biological barriers. But the effect of such derivatives on human cells is still controversially discussed and needs further investigation. Here we assessed the time-dependent effect of a water soluble fullerene derivative that contains five residues of 3-phenylpropionic acid and a chlorine substituent attached to the carbon cage (F-828) on human embryonic lung fibroblasts (HELFs). Investigated substance increases proliferation of HELFs in concentration range 4 nM - 0.1 µM. All concentrations of F-828 cause DNA damage and give rise to reparation process. In concentrations exceeding 20 µM F-828 causes necrotic cell death, blocks apoptosis, and is therefore cytotoxic.
fullerene derivatives, necrosis, HELFs
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