Design and synthesis of new nanomaterials for biomedical applications require a comprehensive assessment of their toxicity in vitro and in vivo . We analyzed the aggregate stability of new types of cerium oxide nanoparticles doped with gadolinium and checked their influence on the proliferative and metabolic activity of human fibroblast in vitro . It has been shown that cerium oxide nanoparticles are not toxic in a wide range of concentrations (10- 5-10-9 M), and are able to stimulate proliferation of the human MSCs in a dose-dependent manner. The high degree of biocompatibility and low toxicity of synthesized nanomaterials allow us to consider it as perspective compound for development of biomedical products.
cerium oxide nanoparticles, proliferative activity, human mesenchymal stem cells
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