Changes of fatty acids composition in the brain lipids of intact mice of Balb line with age increasing from 1 to 24 mounts were studied by capillary gas-liquid and gas chromatography-mass spectrometry. It was found, that occurred with age the content of saturated acids was decreased monotonically, but the content monounsaturated acids was increased, and the content of polyunsaturated acids reached a maximum at 4 months and then decreased. As a result of long-term administration of low doses of oregano essential oil, the level of polyunsaturated fatty acids, (including docosahexaenoic acid, which is responsible for the preservation and maintenance of a number of vital functions of the brain) remained high. The average lifespan of mice, that were administered with essential oil, increased to 120 days.
fatty acids, mice brain, capillary gas-liquid chromatography
1. Nakamura M.T., Cho H.P., Xu J., Clarke S.D. Metabolism and functions of highly unsaturated fatty acids: an update. Lipids, 2001, vol. 36, no. 9, pp. 961-964.
2. Uauy R., Hoffman D.R., Peirano P., Birch D.G., Birch E.E. Essential fatty acids in visual and brain development Lipids, 2001, vol. 36, no. 9, pp. 885-895.
3. Meyers K.J., Rudolf J.L., Mitchell A.E. Influence of dietary quercetin on glutatione redox status in mice. J. Agric. Food Chem., 2008, vol. 56, pp. 830-836.
4. Uauy R., Dangour A.DNutrition in brain development and aging: Role of essential fatty acids. Nutrition Reviews, 2006, vol. 64, no. 5, pp. 24-33.
5. Chalon S., Delion-Vancassel S., Belzung C., Guilloteau D., Legusquet A.M., Besnard J.C. Dietary fish oil affects monoaminergic neurotransmission and behavior in rats. J. Nutr., 1998, vol. 128, pp. 2512-2519.
6. Kaplan R.J., Greenwood C.E. Dietary saturated fatty acids and brain function. Neurochemistry Res., 1998, vol. 23, no. 3, pp. 615-626.
7. Lampley M.S., Walker B.L. A possible essential role for dietary linolenic acid in the development of the young rat. J. Nutr., 1976, vol. 106, pp. 86-93.
8. Rao G., Xia E., Richardson A. Effect of age on the expression of antioxidant enzymes in male Fischer F344 rats. Mechanisms Aging and Develop., 1990, vol. 53, no. 1, pp. 49-60.
9. Recsan Z., Pagliuca G., Piretti MV, Penzes L.G., Youdim K.A., Noble R.C., Deans S.G. Effect of Essential Oils on the Lipids of the Ageing Rat Retinas: A Possible Therapeutic Use. J. Essent. Oil Research., 1997, vol. 9, no. 1, pp. 53-56.
10. Youdim K.A., Deans S.G. Effect of thyme oil and thymol dietary supplementation on the antioxidant status and fatty acid composition of the ageing rat brain. British J. Nutr. 2000, vol. 83, no. 1, pp. 87-93.
11. Deans S.G., Noble RC, Penzes L., Imre S.G. Promotional effects of plant volatile oils on the polyunsaturated fatty acid status during aging. Age, 1993, vol. 16, no. 1, pp. 71-74.
12. Burlakova E.B., Erohin V.N., Misharina T.A., Fatkullina L.D., Kremencova A.V., Semenov V.A., Terenina M.B., Vorob'eva A.K., Goloschapov A.N. Vliyanie letuchih antioksidantov rastitel'nogo proishozhdeniya na razvitie spontannogo leykoza u myshey. Izv RAN. Ser. Biol., 2010, t. 37, № 6, s. 711-718. [Burlakova E.B., Misharina T.A., Fatkullina L.D., Terenina M.B. et al. The effect of volatile antioxidants of plant origin on leukemogenesis in mice. Biology Bull., 2010, vol.37, no.6, pp.612-618. (In Russ.)]
13. Burlakova E.B., Misharina T.A., Fatkullina L.D., Terenina M.B., Krikunova N.I., Erohin V.N., Vorob'eva A.K. Izmeneniya v sostave zhirnyh kislot mozga i pecheni myshey s uvelicheniem vozrasta i pri prieme efirnogo masla chabera. DAN, 2011, t. 437, № 3, s. 409-412. [Burlakova E.B., Misharina T.A., Fatkullina L.D. et al. Alteration in fatty acid composition of mice brain and liver with aging and savory essential oil administration. Doklady Biochemistry and Biophysics, 2011, vol. 437, no. 3, pp. 80-83.]
