Using voltage-clamp technique, the involvement of sigma-1 receptors in the effect of glutoxim on Na+ transport in frog skin was investigated. We have shown that preincubation of the frog skin with sigma-1 receptor antagonist - aminazine - attenuates the stimulatory effect of glutoxim on Na+ transport. The results suggest the possible involvement of the sigma-1 receptors in glutoxim effect on Na+ transport in frog skin epithelium.
frog skin, transepithelial Na+ transport, glutoxim, aminazine
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