We investigated the role of oxidative stress in postpericardiotomic syndrome (PPCS) development mechanism in patients with coronary heart disease (CHD) who underwent direct myocardial revascularization. The study included 76 patients with coronary heart disease aged 46-70 years who performed on the testimony of coronary artery bypass surgery. Patients were divided into two groups. The first group consisted of 66 patients without PPCS, a second - 10 patients with PPCS. Clinical and biochemical examination was performed before and at 1, 3, 5, 7, 10 days after coronary artery bypass surgery were used as controls blood of 10 healthy individuals of both sexes of similar age. The blood and pericardial fluid CHD patients undergoing coronary artery bypass, determined the content of products of lipid peroxidation (diene conjugates, malonic dialdehyde, Schiff bases), the stable metabolite of nitric oxide, asymmetric dimethylarginine (ADMA), arginase activity of antioxidant enzymes (superoxide dismutase, catalase, glutathione), ceruloplasmin oxidase activity and the level of reduced glutathione. The blood and pericardial fluid CHD patients undergoing coronary artery bypass showing intensification of free radical oxidation and the accumulation of lipid peroxidation products; elevated levels of nitric oxide metabolites and activation of arginase ADMA; marked imbalance in the function of superoxide dismutase and catalase in erythrocytes, the tension in the glutathione-dependent enzymes, the inhibition of ceruloplasmin oxidase activity. The described changes are characteristic for the first 5 postoperative days in patients with the PPCS. Thus, in patients with CHD holding direct myocardial revascularization (coronary artery bypass grafting) is accompanied by the development of oxidative and nitrosyl components of oxidative stress.
myocardial revascularization, coronary artery bypass grafting, oxidative stress, postpericardiotomic syndrome, antioxidant enzymes
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