The aim of the work is to study the role of the peripheral blood lymphocyte antioxidant system and apoptosis in assessment the severity of neurodegenerative process in Parkinson's disease (PD). The deep disorders of redox balance and development of oxidative stress in lymphocytes of patients with PD at all stages of the disease have been established. Disorders of redox balance in lymphocytes are characterized by excessive activation of antioxidant enzymes - SOD, glutathione-S-transferase, glutathione reductase on the background of inhibition of catalase and glutathione peroxidase, as well as significant stimulation of prooxidant enzymes - NADPH-oxidase and myeloperoxidase. The activity of glutathione-S-transferase of lymphocytes can be considered as a sensitive and informative test to assess the severity of the pathological process in PD. The most important consequence of the redox balance shift is apoptosis of lymphocytes, which can reflect the CNS cell death level due to unified mechanisms of dopamine metabolism and the similarity of the receptor apparatus components of the immune and nervous system cells.
redox-status, antioxidant enzymes, prooxidants, apoptosis, lymphocytes, Parkinson's disease
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