Analysis of the chemical shifts of exchange protons of deoxyoligonucleotides has been made using two predictive models. The prediction methods are based on sets of published reference chemical shift values and correction factors, which account for shielding or deshielding effects from neighboring nucleotides. The analysis has been made for deoxyheptanucleotide 5'-d (GCGAAGC) forming a hairpin in solution. Theoretical models have shown high accuracy for the values of chemical shifts of protons for double helical B-DNA.
HMR, chemical shift, nucleotide, triplet, hairpin
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