Moscow, Moscow, Russian Federation
Moscow, Moscow, Russian Federation
Moscow, Moscow, Russian Federation
Comparative analysis of the spontaneous aggregation of lecithin in systems with the different polarity and the interrelation between the lipid composition and size of liposomes formed from them by means of ultrasound are performed used the soy bean lecithin and lipids isolated from organs of mice as sources of the natural lipids. Analysis of the experimental data allows us to suppose that the process of the spontaneous aggregation of micelles from the natural lipids in the polar medium depends on the medium properties to more extent than from the quantitative ratio of the phospholipid fractions in lecithin samples. However, the role of the lipid composition including the minor fractions of phospholipids substantially increases under the micelle formation from the natural lipids in the polar medium by means of ultrasound. The understanding of the membrane-genesis in the biological systems is due to a necessity of further Investigations of the micellar formation mechanism from the natural lipids in the polar media.
lecithin, lipids from the organs of mice, dynamic light scattering, phospholipid composition
1. Burlakova, Ye.B., Pal’mina N.P., Mal’tseva Ye.L. A physicochemical system regulating lipid peroxidation in biomembranes during tumor growth. Membrane Lipid Oxidation. Boston: CRC Press, 1991, vol. III, pp. 209-237.
2. Shishkina L.N., Kushnireva E.V., Smotryaeva M.A. Novye podhody k ocenke biologicheskih posledstviy vozdeystviya radiacii v malyh dozah. Radiac. biologiya. Radioekologiya, 2004, t. 44, № 3, s. 289-295. [Shishkina L.N., Kushnireva E.V., Smotryaeva M.A. A new Approach to Assessment of Biological Consequences of Exposure to Low-Dose Radiation. Radiation Biology and Radioecology, 2004, vol. 44, no. 3, pp. 289-295. (In Russ.)]
3. Marakulina K. M., Plaschina I. G., Kozlov M. V., Shishkina L. N. Vliyanie sostava fosfolipidov na ih agregaciyu v nepolyarnom rastvoritele. Butlerovskie soobscheniya, 2011, T. 25, № 7, s. 96-100. [Marakulina K.M., Plashchina I.G., Kozlov M.V., Shishkina L.N. Effect of the phospholipis composition on their aggregation in non-polar solvent. Butlerov Communication, 2011, vol. 25, No. 7. pp. 96-100. (In Russ.)]
4. Shishkina L.N., Kozlov M.V., Marakulina K.M. Plaschina I.G., Plyusnina S.N., Shevchenko O.G., Fedorova I.V., Chukicheva I.Yu., Kuchin A.V. Poverhnostno-aktivnye svoystva izobornilfenolov v sistemah raznoy slozhnosti. Biofizika, 2012, t. 57, vyp. 6, s. 1008-1013. [Shishkina L.N., Kozlov M.V., Marakulina L.M., Plashchina I.G., Plusnina S.N., Shevchenko O.G., Fedorova I.V., Chukicheva I.Yu., Kutchin A.V. Biophysics, 2012, vol. 57, no. 6, pp. 786-791. (In Russ.)]
5. Shishkina L. N., Mazaletskaya L. I., Marakulina K. M., Lukanina Yu. K., Plashchina I. G., Sheludchenko N. I. Effect of complexation with phospholipids and polarity of medium on the reactivity of phenolic antioxidants. Chemistry and Technology of Plant Substances. Toronto, New Jersey: Apple Academic Press, 2017, pp. 93-110 (Chapter 5).
6. Shishkina L.N., Kushnireva Ye.V., Smotryaeva M.A. The combined effect of surfactant and acute irradiation at low dose on lipid peroxidation process in tissues and DNA content in blood plasma of mice. Oxidation commun., 2001, vol. 24, no. 2, pp. 276-286.
7. Brin E.F., Travin S.O. Modelirovanie mehanizmov himicheskih reakciy. Him. fizika, 1991, t. 10, s. 830-837. [Brin E.F., Travin S.O. Modeling the chemical reaction mechanism. Chem. Physics, 1991. vol. 10, no. 6, pp. 830-837. (In Russ.)]
8. Klimovich M.A., Shishkina L.N., Paramonov D.V., Trofimov V.I. Interrelation between the physicochemical properties and the composition of natural lipids and the liposomes formed from them. Oxidation Commun., 2010, vol. 33, no. 4, pp. 965-973.
9. Klimovich M.A., Paramonov D.V., Kozlov M.V., Trofimov V.I., Shishkina L.N. Interrelation between the Peroxidation Parameters of Natural Lipids and the Liposomes Characteristics Formed from Them. Modern Problems in Biochemical Physics. New Horizons. N.Y.: Nova Science Publishers, 2012, pp. 255-262 (Chapter 32).
10. Shishkina L.N., Klimovich M.A., Kozlov M.V. Functioning Similarity of the Physicochemical Regulatory System Parameters of the Lipid Peroxidation on the Membrane and Organ Levels. Pharmaceutical and Medical Biotechnology. New Perspectives. N.Y.: Nova Science Publishers, 2013, pp. 151-157 (Chapter 14).
