The paper is devoted to mathematical modeling of transgenic microbial populations (GMO) dynamics during cultivation in the chemostat. Even at present time we do not completely understand why and how transgenic microorganisms are unstable during prolonged butch or chemostat cultivation. The exact mechanisms by which containing cloned genes plasmid-bearing cells grow at a slower rate than their plasmid-free counterparts are also unclear whether it is a direct effect of plasmid gene expression on the viability of plasmid-bearing cells, inhibition of the cell growth, or the use of cell resources on plasmid maintenance. Estimation of the plasmid instability parameters according to the methods developed in this paper is the first step in understanding the major causes of why transgenic microorganisms plasmids are lost in culture or not lost in nature (plasmids paradox).
transgenic microorganisms, plasmids unstability, mathematical modeling, cost of plasmids, continuous cultures of microorganisms, chemostat
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