A significant increase in the intracellular concentration of lithium was revealed after exposure of erythrocytes to 6-10 mM Li2SO4 for 3 hours. The accumulation of lithium ions in erythrocytes is accompanied by inhibition of their esterase activity, a slight decrease in the level of reactive oxygen species and an increase in the permeability of the cell membrane. It has been shown that the effect of lithium salts in toxic concentrations on human erythrocytes in vitro slightly reduces the level of reactive oxygen species, but leads to a modification of the physicochemical state of membrane-bound proteins and lipids. The results obtained are the basis for creating a cell test system for assessing the toxicity of lithium.
erythrocytes, lithium, trace elements, reactive oxygen species, lipid microviscosity, membrane-bound proteins
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