Lomonosov Moscow State University
Moscow, Moscow, Russian Federation
E.I. Chazov National Medical Research Centre of Cardiology
Moscow, Moscow, Russian Federation
E.I. Chazov National Medical Research Centre of Cardiology
Moscow, Moscow, Russian Federation
Moscow, Moscow, Russian Federation
Lomonosov Moscow State University
Moscow, Moscow, Russian Federation
The paper considers the effect of dinitrosyl iron complexes (DNIC) on the processes of free radical lipid peroxidation, which make a significant contribution to the development of many pathological conditions. These processes damage lipids and other macromolecules, and, in addition, the end products of lipid peroxidation are mutagens and carcinogens. The search for new antioxidant compounds capable of inhibiting lipid peroxidation has a fairly long history, but there are still many questions, including those related to potential clinical applications. In the framework of this work, data were obtained that allow expanding and supplementing the idea of DNIC as significant antioxidant agents. With the use of EPR spectroscopy and spectrophotometry, it was shown that dinitrosyl iron complexes are able to inhibit lipid peroxidation in model systems with tert-butyl hydroperoxide and cytochrome C, as well as in experiments with low-density lipoproteins during their oxidation with copper ions. Presumably, DNIC can be used as a therapeutic agent that prevents or reduces lipid damage and the accumulation of toxic end products of lipid peroxidation.
lipid peroxidation, dinitrosyl iron complexes, antioxidants, EPR spectroscopy
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