Baku, Azerbaijan
Baku, Azerbaijan
Baku, Azerbaijan
The conformational capabilities of soymorphine-5 (Thr1-Pro2-Phe3-Val4-Val5-NH2), soymorphine-6 (Tyr1-Pro2-Phe3-Val4-Val5-Asn6-NH2) and soymorphine-7 (Tyr1- Pro2-Tyr3-Val4-Val5-Asn6-Ala7-NH2) molecules have been studied by the method of theoretical conformational analysis. The potential function of the system is chosen as the sum of non-valence, electrostatic and torsion interactions and the energy of hydrogen bonds. The low-energy conformations of soymorphine-5, soymorphine-6 and soymorphine-7 molecules were found, the dihedral angles of the main and side chains of amino acid residues that make up the molecule were found, and the energy of intra- and interresidual interactions was estimated. Thus, the spatial structure of soymorphine-5, soymorphine-6 and soymorphine-7 molecules can be represented by eight structural types. It can be assumed that the molecules perform their physiological functions in these structures. Comparison of the low-energy structures of soymorphins shows that in all molecules the first four low-energy conformations are representatives of the structural types efef, efee, efff, effe for soymorphine-5, effff, efeff, efffe, effee for soymorphine-6, efffff, efeffe, efffef, effeee for soymorphine-6. soymorphine-7. On the basis of these structures, it is possible to propose their artificial analogues for synthesis. It was shown that the spatial structure of soymorphine-5, soymorphine-6 and soymorphine-7 molecules is represented by the conformations of eight shapes of the peptide skeleton. The results obtained can be used to elucidate the structural and structural-functional organization of soymorphine molecules.
exorphin, soymorphin, opioid, structure, conformation
1. Chesnokova E.A., Sarycheva N.Y., Dubynin V.A., Kamensky A.A. Food-Derived Opioid Peptides and Their Neurological Impact. Advancesin Physiological Sciences, 2015, vol. 46, no. 1, pp. 22-46 (In Russ.).
2. Sokolov O.Yu., Kost N.V., Andreeva O.O., Korneeva E.V., MeshavkinV.K., Tarakanova Yu.N., Dadayan A.K., Zolotarev Yu.A., Grachev S.A., Mikheeva I.G., Zozulya A.A. The possibl eroleof casomorphin sinpathogenesis of autism. Psixiatriya, 2010, vol. 46, no. 3, pp.29-35 (In Russ.).
3. Sienkiewiez-Szlapka E., Jarmolowska B., Krawczuk S., Kostyara E. Contents of agonistic and antagonistic opioid peptides in different cheese varieties. Int. Dairy J., 2009, vol. 19, no. 4, pp. 258-263.
4. Akhmedov N.A. Teoretical conformation analysis of β-cazomorphin, valmuceptin and morphiceptin molecules. Molecular. Biol., 1989, 23, 240-240(In Russ.).
5. Akhmedov N.A., Godjaev N.M., Suleymanova E.V., Popov E.M. Structural organization of the [Met] encephalin and endorphins molecules. Bioorganic chemistry, 1990, vol. 16, pp. 649-667 (In Russ.).
6. Gadjieva Sh.N., Akhmedov N.A., Masimov E.A., Godjaev N.M. Spatial Structure of Thr-Pro-Ala-Glu-Asp-Phe-Met-Arg-Phe-NH2. Biophysics, 2013, vol. 58, pp. 587-590 (In Russ.).
7. Akhmedov N.A., Ismailova L.I., Abbasli R.M. et al. Spatial Structure of Octarphin molecule. IOSR J. Applied Physics (IOSR-JAP), 2016, vol. 8, pp.66-70.
8. Ismailova L.I., Abbasli R.M., Akhmedov N. Computer Modeling of the Spatial Structure of Nonapeptide Molecule. COIA 2020, Baku, Azerbaijan, vol. I, pp. 218-221.
9. Akhmedov N.A., Agayeva L.N., Akverdieva G.A., Abbasli R.M., Ismailova L.I. Spatial structure of the ACTH-(6-9)-PGP molecule. J. Chem. Soc. Pak., 2021, vol. 43, no. 05, pp. 500-504.
10. Akhmedov N.A., Agayeva L.N., Akhmedova S.R., Abbasli R.M., Ismailova L.I. Spatial structure of the β-Casomorphin-7 Molecule. IOSR Journal of Applied Physics (IOSR-JAP), 2021, vol.13, iss. 5, ser. II, pp. 62-67, doi:https://doi.org/10.9790/4861-1305026267.
11. Agayeva L.N., Abdinova A.A., Akhmedova S.R., Akhmedov N.A. Spatial Structure of the ACTH-(7-10) Molecule. Biophysics, 2021, vol. 66, no. 4, pp. 531-534.
12. Akhmedov N.A., Abbasli R.M., Agayeva L.N., Ismailova L.I. Three-dimensional structure of exorpin B5 molecule. Conference proceedings Modern Trends in Physics, 2019, pp. 201-104.
13. IUPAC-IUB. Quantities, Units and Symbols in Physical Chemistry, Blackwell Scientific, Oxford 1993.
