Saint Petersburg, St. Petersburg, Russian Federation
Saint Petersburg, St. Petersburg, Russian Federation
from 01.01.2023 until now
Kirov Military Medical Academy
Saint Petersburg, St. Petersburg, Russian Federation
Saint Petersburg, St. Petersburg, Russian Federation
Saint Petersburg, St. Petersburg, Russian Federation
The article is devoted to the study of redox regulation of transepithelial ion transport in osmoregulatory epithelium. The pharmacological analogue of oxidized glutathione, drug glutoxim®, has antioxidant and radioprotective properties and is widely used as an immunomodulator and cytoprotector in complex therapy of bacterial, viral and oncological diseases. Using voltage-clamp technique, the influence of non-steroidal anti-inflammatory drug meloxicam, an inhibitor of the cyclooxygenase pathway of arachidonic acid oxidation, on glutoxim effect on Na+ transport in frog Rana temporaria skin was investigated. It was shown for the first time that frog skin preincubation with meloxicam significantly reduces the stimulatory effect of glutoxim on Na+ transport. The data obtained indicate the involvement of cyclooxygenase pathway of arachidonic acid oxidation in the effect of glutoxim on Na+ transport in frog skin epithelium. The results also contribute to a more detailed understanding of molecular mechanisms of pharmacological effect of glutoxim and meloxicam, and may be useful for their application in clinics.
Na+ transport, glutoxim, meloxicam, frog skin epithelium
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