Показана принципиальная возможность диагностики рака легкого и молочной железы с использованием метода ИК-Фурье-спектроскопии. Статистически достоверные отличия для ИК-спектров слюны больных раком легкого наблюдаются в спектральном диапазоне 1070-1240 см-1 и могут быть отнесены к нуклеиновым кислотам. Для группы пациентов с раком молочной железы отличий в спектрах значительно больше: различаются по интенсивности полосы поглощения фосфодиэфирных групп, нуклеиновых кислот и фосфолипидов (1300 и 800 см-1), метильных и метиленовых групп молекул белков, липидов, а также карбоксильных групп жирных кислот и аминокислот (1500-1300 см-1), ДНК и РНК (1700-1580 см-1), а также метильных и метиленовых групп насыщенных и ненасыщенных алкильных цепей (3050-2800 см-1). Выявлены коэффициенты I1398/1454 и I1240/1310, изменение которых на фоне онкологической патологии статистически достоверно.
слюна, инфракрасная спектроскопия, диагностика, рак легкого, рак молочной железы
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