В работе исследовали уровни оксида азота, провоспалительных цитокинов (IL-1β, IL-6, IL-18, TNFα), лептина и мочевой кислоты в плазме крови и синовиальной жидкости (СЖ) как биомаркеров посттравматического гонартроза (ПТГА), а также их ассоциацию с рентгенологической стадией ПТГА. Установлено, что у пациентов с ранними и поздними стадиями посттравматического артроза коленного сустава повышен уровень циркулирующих провоспалительных медиаторов: нитритов/нитратов (NOx-), IL-6 и мочевой кислоты по сравнению со здоровыми лицами. Циркулирующие уровни NOx-, IL-1β, IL-6, мочевой кислоты, лептина и комбинации IL-6 и лептина могут быть потенциальными диагностическими тестами в соответствии с результатами ROC-анализа. Уровни NOx-, IL-6, IL-18 и лептина в плазме достоверно коррелировали с их содержанием в СЖ. Тяжесть ПTГA коррелировала с уровнем лептина в плазме и СЖ, а также с уровнем синовиального IL-18. Исследована ассоциация полиморфных вариантов генов nNOS и eNOS с риском развития посттравматического гонартроза (ПТГА) у жителей Ростовской области. Установлено, что аллель -84A полиморфного гена nNOS ассоциирован с риском развития ПТГА.
посттравматический гонартроз, плазма крови, синовиальная жидкость, оксид азота, провоспалительные цитокины, лептин, гены NO-синтаз
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