Due to the wide spread of multidrug resistant pathogens in world medical practice, there is a high demand for antibiotics belonging to the chemical group of peptides (in particular, glycopeptides), due to their significant antibacterial activity against multidrug-resistant pathogens. At the moment, this group of antibiotics in the nomenclature of antibacterial medicines includes daptomycin, ramoplanin, teicoplanin and vancomycin. Antibiotics of this group have activity against gram-positive bacteria and mycobacteria, including Mycobacterium tuberculosis. The advantage of glycopeptide antibiotics over a number of antibiotics of other groups is the bactericidal type of action and high activity against microorganisms resistant to many drugs, including β-lactam antibiotics and fluoroquinolones. According to the World Health Organization (WHO), the resistance of pathogens to antibiotics is the main challenge facing modern healthcare. The problem of the rapid spread of resistant forms among pathogenic microorganisms is exacerbated by the lack of a sufficient number of effective antibiotics in modern medicine. According to the World Health Organization, from 2000 to 2015, only 2 new natural antibiotics for clinical trials have been approved worldwide.
peptide antibiotics, antimicrobial activity, bacterial strains-producers, structure
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